| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Minireview |
a Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305
Cyclic AMP signaling is involved in most aspects of differentiation and maturation of the granulosa cells in the ovarian follicle. As the genetic programs activated at different stages of follicle growth maturation are being elucidated, it is becoming increasingly difficult to reconcile the simplicity of the cAMP cascade with the complexity and the divergent patterns of gene expression activated in these cells. To account for these divergent outcomes of the cAMP signal, three aspects of this signaling cascade in granulosa cells will be reviewed. We will discuss the evidence for gonadotropin receptors coupling to different G proteins and effectors. Next, we will explore the possibility that the temporal and spatial dimensions of the cAMP signal itself may contribute to the diverse outcomes. Finally, we will summarize available data showing that the cAMP signal is distributed through several cascades of kinase activation. It is hoped this compendium will provide a framework with which to understand how the initial signals activated by gonadotropins control the complex patterns of gene expression that are required for follicle maturation and ovulation.
This article has been cited by other articles:
|
|
 |
|
  P. Filis, T. Lannagan, A. Thomson, A. A. Murray, P. C. Kind, and N. Spears Phospholipase C-{beta}1 Signaling Affects Reproductive Behavior, Ovulation, and Implantation Endocrinology, July 1, 2009; 150(7): 3259 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sasseville, M.-C. Gagnon, C. Guillemette, R. Sullivan, R. B. Gilchrist, and F. J. Richard Regulation of Gap Junctions in Porcine Cumulus-Oocyte Complexes: Contributions of Granulosa Cell Contact, Gonadotropins, and Lipid Rafts Mol. Endocrinol., May 1, 2009; 23(5): 700 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sayasith, N. Bouchard, M. Dore, and J. Sirois Regulation of Bovine Tumor Necrosis Factor-{alpha}-Induced Protein 6 in Ovarian Follicles during the Ovulatory Process and Promoter Activation in Granulosa Cells Endocrinology, December 1, 2008; 149(12): 6213 - 6225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sasseville, N. Cote, M.-C. Gagnon, and F. J. Richard Up-Regulation of 3'5'-Cyclic Guanosine Monophosphate-Specific Phosphodiesterase in the Porcine Cumulus-Oocyte Complex Affects Steroidogenesis during in Vitro Maturation Endocrinology, November 1, 2008; 149(11): 5568 - 5576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Panigone, M. Hsieh, M. Fu, L. Persani, and M. Conti Luteinizing Hormone Signaling in Preovulatory Follicles Involves Early Activation of the Epidermal Growth Factor Receptor Pathway Mol. Endocrinol., April 1, 2008; 22(4): 924 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kajitani, S. Liu, T. Maruyama, H. Uchida, R. Sakurai, H. Masuda, T. Nagashima, M. Ono, T. Arase, and Y. Yoshimura Analysis of serum FSH bioactivity in a patient with an FSH-secreting pituitary microadenoma and multicystic ovaries: A case report Hum. Reprod., February 1, 2008; 23(2): 435 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Looyenga and G. D. Hammer Genetic Removal of Smad3 from Inhibin-Null Mice Attenuates Tumor Progression by Uncoupling Extracellular Mitogenic Signals from the Cell Cycle Machinery Mol. Endocrinol., October 1, 2007; 21(10): 2440 - 2457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sen, A. Bettegowda, F. Jimenez-Krassel, J. J. Ireland, and G. W. Smith Cocaine- and Amphetamine-Regulated Transcript Regulation of Follicle-Stimulating Hormone Signal Transduction in Bovine Granulosa Cells Endocrinology, September 1, 2007; 148(9): 4400 - 4410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L Al-Musawi, R. T Gladwell, and P. G Knight Bone morphogenetic protein-6 enhances gonadotrophin-dependent progesterone and inhibin secretion and expression of mRNA transcripts encoding gonadotrophin receptors and inhibin/activin subunits in chicken granulosa cells Reproduction, August 1, 2007; 134(2): 293 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Needle, K. Piparo, D. Cole, C. Worrall, I. Whitehead, G. Mahon, and L. T. Goldsmith Protein Kinase A-Independent cAMP Stimulation of Progesterone in a Luteal Cell Model Is Tyrosine Kinase Dependent but Phosphatidylinositol-3-Kinase and Mitogen-Activated Protein Kinase Independent Biol Reprod, July 1, 2007; 77(1): 147 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Priyanka and R. Medhamurthy Characterization of cAMP/PKA/CREB signaling cascade in the bonnet monkey corpus luteum: expressions of inhibin-{alpha} and StAR during different functional status Mol. Hum. Reprod., June 1, 2007; 13(6): 381 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sasseville, N. Cote, C. Vigneault, C. Guillemette, and F. J. Richard 3'5'-Cyclic Adenosine Monophosphate-Dependent Up-Regulation of Phosphodiesterase Type 3A in Porcine Cumulus Cells Endocrinology, April 1, 2007; 148(4): 1858 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K E Ryan, S M Casey, M J Canty, M A Crowe, F Martin, and A C O Evans Akt and Erk signal transduction pathways are early markers of differentiation in dominant and subordinate ovarian follicles in cattle Reproduction, March 1, 2007; 133(3): 617 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lindeberg, K. Carlstrom, O. Ritvos, and O. Hovatta Gonadotrophin stimulation of non-luteinized granulosa cells increases steroid production and the expression of enzymes involved in estrogen and progesterone synthesis Hum. Reprod., February 1, 2007; 22(2): 401 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vasta, M. Shimizu-Albergine, and J. A. Beavo Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A PNAS, December 26, 2006; 103(52): 19925 - 19930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M Silva, M Hamel, M Sahmi, and C A Price Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro. Reproduction, December 1, 2006; 132(6): 909 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Takahashi, J. D. Morrow, H. Wang, and S. K. Dey Cyclooxygenase-2-derived Prostaglandin E2 Directs Oocyte Maturation by Differentially Influencing Multiple Signaling Pathways J. Biol. Chem., December 1, 2006; 281(48): 37117 - 37129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O Gubbay, M T Rae, A S McNeilly, F X Donadeu, A J Zeleznik, and S G Hillier cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival. J. Endocrinol., October 1, 2006; 191(1): 275 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Conti, M. Hsieh, J.-Y. Park, and Y.-Q. Su Role of the Epidermal Growth Factor Network in Ovarian Follicles Mol. Endocrinol., April 1, 2006; 20(4): 715 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Amireault and F. Dube Intracellular cAMP and Calcium Signaling by Serotonin in Mouse Cumulus-Oocyte Complexes Mol. Pharmacol., December 1, 2005; 68(6): 1678 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. X. Donadeu and M. Ascoli The Differential Effects of the Gonadotropin Receptors on Aromatase Expression in Primary Cultures of Immature Rat Granulosa Cells Are Highly Dependent on the Density of Receptors Expressed and the Activation of the Inositol Phosphate Cascade Endocrinology, September 1, 2005; 146(9): 3907 - 3916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Ongeri, M. F. Verderame, and J. M. Hammond Follicle-Stimulating Hormone Induction of Ovarian Insulin-Like Growth Factor-Binding Protein-3 Transcription Requires a TATA Box-Binding Protein and the Protein Kinase A and Phosphatidylinositol-3 Kinase Pathways Mol. Endocrinol., July 1, 2005; 19(7): 1837 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Zhang, Y Tao, B Zhou, H Xie, F Wang, L Lei, L Huo, Q Sun, and G Xia Atrial natriuretic peptide inhibits the actions of FSH and forskolin in meiotic maturation of pig oocytes via different signalling pathways J. Mol. Endocrinol., April 1, 2005; 34(2): 459 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. McKenna, M. Pietropaolo, E. G. Tos, A. Clark, D. Fischer, D. Kagan, B. Bao, P. J. Chedrese, and S. Palmer Pharmacological Inhibition of Phosphodiesterase 4 Triggers Ovulation in Follicle-Stimulating Hormone-Primed Rats Endocrinology, January 1, 2005; 146(1): 208 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E C Chin, T E Harris, and D R E Abayasekara Changes in cAMP-dependent protein kinase (PKA) and progesterone secretion in luteinizing human granulosa cells J. Endocrinol., October 1, 2004; 183(1): 39 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Walzel, J. Brock, R. Pohland, J. Vanselow, W. Tomek, F. Schneider, and U. Tiemann Effects of galectin-1 on regulation of progesterone production in granulosa cells from pig ovaries in vitro Glycobiology, October 1, 2004; 14(10): 871 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Saxena, R. Safi, L. Little-Ihrig, and A. J. Zeleznik Liver Receptor Homolog-1 Stimulates the Progesterone Biosynthetic Pathway during Follicle-Stimulating Hormone-Induced Granulosa Cell Differentiation Endocrinology, August 1, 2004; 145(8): 3821 - 3829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sasson, E. Rimon, A. Dantes, T. Cohen, V. Shinder, A. Land-Bracha, and A. Amsterdam Gonadotrophin-induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic genes, cytoskeletal genes and genes coding for apoptotic signalling and protein kinases Mol. Hum. Reprod., May 1, 2004; 10(5): 299 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kalma, I. Granot, D. Galiani, A. Barash, and N. Dekel Luteinizing Hormone-Induced Connexin 43 Down-Regulation: Inhibition of Translation Endocrinology, April 1, 2004; 145(4): 1617 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sayasith, N. Bouchard, M. Sawadogo, J. G. Lussier, and J. Sirois Molecular Characterization and Role of Bovine Upstream Stimulatory Factor 1 and 2 in the Regulation of the Prostaglandin G/H Synthase-2 Promoter in Granulosa Cells J. Biol. Chem., February 20, 2004; 279(8): 6327 - 6336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hreinsson, B. Rosenlund, B. Friden, L. Levkov, I. Ek, A.-M. Suikkari, O. Hovatta, and M. Fridstrom Recombinant LH is equally effective as recombinant hCG in promoting oocyte maturation in a clinical in-vitro maturation programme: a randomized study Hum. Reprod., October 1, 2003; 18(10): 2131 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Zeleznik, D. Saxena, and L. Little-Ihrig Protein Kinase B Is Obligatory for Follicle-Stimulating Hormone-Induced Granulosa Cell Differentiation Endocrinology, September 1, 2003; 144(9): 3985 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ramaswamy, G. R. Marshall, C. R. Pohl, R. L. Friedman, and T. M. Plant Inhibitory and Stimulatory Regulation of Testicular Inhibin B Secretion by Luteinizing Hormone and Follicle-Stimulating Hormone, Respectively, in the Rhesus Monkey (Macaca mulatta) Endocrinology, April 1, 2003; 144(4): 1175 - 1185. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
