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BOR - Papers in Press, published online ahead of print October 4, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.007682
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Biology of Reproduction 67, 1881-1887 (2002)
DOI: 10.1095/biolreprod.102.007682 © 2002 Society for the Study of Reproduction, Inc.

Mechanisms of Hormone Action

Sex Steroid Hormones Enhance Hypotensive Effects of Calcitonin Gene-Related Peptide in Aged Female Rats1

P.R.R. Gangulaa, S.J. Wimalawansab, and C. Yallampalli2,a

a Department of Obstetrics/Gynecology, University of Texas Medical Branch, Galveston, Texas 77555-1062 b Department of Endocrinology, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903-0019

The aim of the present study is to investigate whether vascular protective effects of steroid hormones in aged female rats are mediated through calcitonin gene-related peptide (CGRP), a known potent vasodilator. This rat model reflects the postmenopausal state in humans. We examined whether blood pressure lowering effects of CGRP are enhanced in aged female rats when steroid hormone treatments are administered. We observed that 1) continuous infusion of CGRP lowered blood pressures in rats treated with estradiol-17ß and progesterone (P < 0.05), 2) acute hypotensive effects of CGRP were significantly (P < 0.05) greater in the presence of steroid hormones than in vehicle-treated groups, 3) blood pressure decreases in response to CGRP are lower in aged female rats than they are in young adult ovariectomized rats, and 4) age-related differences in the hypotensive effects of CGRP were nullified when animals were treated with steroid hormones. These data suggest that female sex steroid hormones may modulate arterial blood pressure by regulating the CGRP effector system in female rats regardless of age.

1 P.R.R.G. was supported by grant AG-18999-01 from the National Institute of Aging and by the Sealy Center for Aging at the University of Texas Medical Branch, Galveston, Texas. C.Y. was supported by grant HL-58144 from the National Heart, Lung, and Blood Institute, and by grant HD-40828 from the National Institute on Child Health and Human Development.

2 Correspondence: Chandrasekhar Yallampalli, Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Medical Research Building, Room 11.138, Galveston, TX 77555-1062; FAX: 409 747 0475; chyallam{at}utmb.edu






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