Biol Reprod Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print October 23, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.005959
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
68/2/363    most recent
biolreprod.102.005959v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scheffen, J. R.
Right arrow Articles by Bauer-Dantoin, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scheffen, J. R.
Right arrow Articles by Bauer-Dantoin, A. C.
Agricola
Right arrow Articles by Scheffen, J. R.
Right arrow Articles by Bauer-Dantoin, A. C.
BIOLOGY OF REPRODUCTION 68, 363–369 (2003)
DOI: 10.1095/biolreprod.102.005959
© 2003 by the Society for the Study of Reproduction, Inc.

Pituitary

Testosterone-Dependent Effects of Galanin on Pituitary Luteinizing Hormone Secretion in Male Rats1

Joseph R. Scheffena, Cynthia L. Spletta, Joshua A. Desotellea, and Angela C. Bauer-Dantoin2,a

a Department of Human Biology, University of Wisconsin-Green Bay, Green Bay, Wisconsin 54311-7001

Galanin is a 29-amino-acid peptide that colocalizes with GnRH in hypothalamic neurons. High concentrations of galanin are present in portal vessel blood of both male and female rats, and galanin receptors are present on gonadotropes in both sexes. Results from studies of female rats indicate that galanin acts at the level of the pituitary to directly stimulate LH secretion and also to enhance GnRH-stimulated LH secretion. The effects of galanin on pituitary LH secretion in male rats are relatively uncharacterized; thus, the present in vivo study was conducted 1) to examine the ability of galanin to affect basal or GnRH-stimulated LH secretion in male rats and 2) to determine whether the effects of galanin on LH secretion in male rats are testosterone-dependent. All three doses of galanin used (1, 5, and 10 µg/pulse) significantly enhanced GnRH-stimulated LH secretion in intact male rats. Only the highest dose of galanin directly stimulated LH secretion (without GnRH coadministration) in intact males. Galanin did not directly stimulate LH secretion or enhance GnRH-stimulated LH secretion in castrated male rats. In fact, the highest dose of galanin inhibited GnRH-stimulated LH secretion in castrated males. Upon testosterone replacement, the ability of galanin to directly stimulate LH secretion and to enhance GnRH-stimulated LH secretion was restored in castrated males. These results suggest a role for galanin in the regulation of LH release in male rats and demonstrate that testosterone upregulates the ability of the pituitary to respond to the stimulatory effects of galanin.

1 Supported by NIH Academic Research Enhancement Award R15-HD37951-01 (to A.B.D.).

2 Correspondence: Angela Bauer-Dantoin, University of Wisconsin-Green Bay, Department of Human Biology, Environmental Sciences Building, Room 301, 2420 Nicolet Drive, Green Bay, WI 54311-7001. FAX: 920 465 2769: bauera{at}uwgb.edu






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Society for the Study of Reproduction.