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BOR - Papers in Press, published online ahead of print October 30, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.010876
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BIOLOGY OF REPRODUCTION 68, 1079–1086 (2003)
DOI: 10.1095/biolreprod.102.010876
© 2003 by the Society for the Study of Reproduction, Inc.

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Improvements in Cloning Efficiencies May Be Possible by Increasing Uniformity in Recipient Oocytes and Donor Cells

Kazuchika Miyoshia, S. Jacek Rzucidlob, Scott L. Prattb, and Steven L. Stice1,a,b

a Department of Animal and Dairy Science, University of Georgia, Athens, Georgia 30602-2771 b ProLinia, Inc., Athens, Georgia 30602-2771

The low efficiency of somatic cell cloning is the major obstacle to widespread use of this technology. Incomplete nuclear reprogramming following the transfer of donor nuclei into recipient oocytes has been implicated as a primary reason for the low efficiency of the cloning procedure. The mechanisms and factors that affect the progression of the nuclear reprogramming process have not been completely elucidated, but the identification of these factors and their subsequent manipulation would increase cloning efficiency. At present, many groups are studying donor nucleus reprogramming. Here, we present an approach in which the efficiency of producing viable offspring is improved by selecting recipient oocytes and donor cells that will produce cloned embryos with functionally reprogrammed nuclei. This approach will produce information useful in future studies aimed at further deciphering the nuclear reprogramming process.

1 Correspondence: Steven L. Stice, Department of Animal and Dairy Science, University of Georgia, 425 River Rd., Athens, GA 30602-2771. FAX: 706 542 7925; sstice{at}arches.uga.edu






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Copyright © 2003 by the Society for the Study of Reproduction.