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BOR - Papers in Press, published online ahead of print December 11, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.009761
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BIOLOGY OF REPRODUCTION 68, 1787–1792 (2003)
DOI: 10.1095/biolreprod.102.009761
© 2003 by the Society for the Study of Reproduction, Inc.

Female Reproductive Tract

Decysin, a New Member of the Metalloproteinase Family, Is Regulated by Prolactin and Steroids During Mouse Pregnancy1

Nathalie Baran, Paul A. Kelly, and Nadine Binart2

INSERM Unité 344, Endocrinologie Moléculaire, Faculté de Médecine Necker, 75730 Paris Cedex 15, France

More than 300 separated actions have been attributed to prolactin (PRL), which could be correlated to the quasi-ubiquitous distribution of its receptor. Null mutation of the PRL receptor (PRLR) gene leads to female sterility caused by a failure of embryo implantation. Using the PRLR knockout mouse model and the mRNA differential display method, among 45 isolated genes, we identified UA+4 as a PRL and steroids-target gene during the peri-implantation period that encodes the decysin. Hormonally regulated in the uterus during pregnancy, this new member of disintegrin metalloproteinase is present in the uterus at the site of blastocyst apposition in nondifferentiated stromal cells at the antimesometrial pole and, interestingly, is colocalized with the PRLR. At midpregnancy, decysin expression persists specifically at the foeto-maternal junction around vessels. Although it has been previously suggested that decysin expression is related to immune function, its function during pregnancy remains to be clearly established.

1 Supported in part by grants from INSERM, la Fondation pour la Recherche Médicale, Organon FARO 61/subv.99, and ARC 9952.

2 Correspondence: Nadine Binart, INSERM U-344, Faculté de Médecine Necker Enfants malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France. FAX: 33 1 43 06 04 43; binart{at}necker.fr




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Copyright © 2003 by the Society for the Study of Reproduction.