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BOR - Papers in Press, published online ahead of print January 8, 2003.
Biol Reprod 2003, 10.1095/biolreprod.102.012880
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biolreprod.102.012880v1
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BIOLOGY OF REPRODUCTION 68, 2024–2032 (2003)
DOI: 10.1095/biolreprod.102.012880
© 2003 by the Society for the Study of Reproduction, Inc.

Ovary

Immunocontraception Is Induced in BALB/c Mice Inoculated With Murine Cytomegalovirus Expressing Mouse Zona Pellucida 31

Megan L. Lloyd3, Geoffrey R. Shellam3, John M. Papadimitriou4, and Malcolm A. Lawson2,3

Microbiology, School of Biomedical and Chemical Sciences,3 University of Western Australia, QEII Medical Centre, Nedlands, Western Australia, 6009 Australia Pathology, School of Surgery and Pathology,4 University of Western Australia, Nedlands, Western Australia, 6009 Australia

Immunocontraception, the prevention of oocyte fertilization through immunological means, could potentially be used to control plaguing mouse populations in Australia. This paper describes the construction of a mouse-specific betaherpesvirus, murine cytomegalovirus, which has been engineered to express the murine zona pellucida 3 (ZP3) gene. A single inoculation of this recombinant virus resulted in almost complete infertility, persistent anti-ZP3 antibody production, and profound changes to ovarian morphology in BALB/c mice in the absence of significant virus replication during the acute phase of infection. Murine cytomegalovirus may prove to be useful as a vector for the delivery of a mouse-specific immunocontraceptive agent to target populations of wild mice in the field.

1 This work was funded by the Grains Research Development Corporation and the Pest Animal Control Cooperative Research Centre.

2 Correspondence: Malcolm A. Lawson, Department of Microbiology, UWA, QEII Medical Centre, Nedlands, Western Australia, 6009 Australia. FAX: 61 08 93462912; mlawson{at}cyllene.uwa.edu.au




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