|
|
||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Minireviews |
Department of Anatomy II, University of Technology Aachen, D-52057 Aachen, Germany
Maternal uteroplacental blood flow increases during pregnancy. Altered uteroplacental blood flow is a core predictor of abnormal pregnancy. Normally, the uteroplacental arteries are invaded by endovascular trophoblast and remodeled into dilated, inelastic tubes without maternal vasomotor control. Disturbed remodeling is associated with maintenance of high uteroplacental vascular resistance and intrauterine growth restriction (IUGR) and preeclampsia. Herein, we review routes, mechanisms, and control of endovascular trophoblast invasion. The reviewed data suggest that endovascular trophoblast invasion involves a side route of interstitial invasion. Failure of vascular invasion is preceded by impaired interstitial trophoblast invasion. Extravillous trophoblast synthesis of nitric oxide is discussed in relation to arterial dilation that paves the way for endovascular trophoblast. Moreover, molecular mimicry of invading trophoblast-expressing endothelial adhesion molecules is discussed in relation to replacement of endothelium by trophoblast. Also, maternal uterine endothelial cells actively prepare endovascular invasion by expression of selectins that enable trophoblast to adhere to maternal endothelium. Finally, the mother can prevent endovascular invasion by activated macrophage-induced apoptosis of trophoblast. These data are partially controversial because of methodological restrictions associated with limitations of human tissue investigations and animal studies. Animal models require special care when extrapolating data to the human due to extreme species variations regarding trophoblast invasion. Basal plates of delivered placentas or curettage specimens have been used to describe failure of trophoblast invasion associated with IUGR and preeclampsia; however, they are unsuitable for these kinds of studies, since they do not include the area of pathogenic events, i.e., the placental bed.
This article has been cited by other articles:
![]() |
Y. Ginosar, M. Nadjari, A. Hoffman, N. Firman, E. M. Davidson, C. F. Weiniger, L. Rosen, C. Weissman, U. Elchalal, and the ACET study group Antepartum continuous epidural ropivacaine therapy reduces uterine artery vascular resistance in pre-eclampsia: a randomized, dose-ranging, placebo-controlled study Br. J. Anaesth., March 1, 2009; 102(3): 369 - 378. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Osol and M. Mandala Maternal Uterine Vascular Remodeling During Pregnancy Physiology, February 1, 2009; 24(1): 58 - 71. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Yamamoto, K. Ino, E. Miyoshi, K.-i. Inamori, A. Abe, S. Sumigama, A. Iwase, H. Kajiyama, K. Shibata, A. Nawa, et al. N-Acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of {alpha}5{beta}1 Integrin Endocrinology, February 1, 2009; 150(2): 990 - 999. [Abstract] [Full Text] [PDF] |
||||
![]() |
W.-H. Zhou, M.-R. Du, L. Dong, J. Yu, and D.-J. Li Chemokine CXCL12 promotes the cross-talk between trophoblasts and decidual stromal cells in human first-trimester pregnancy Hum. Reprod., December 1, 2008; 23(12): 2669 - 2679. [Abstract] [Full Text] [PDF] |
||||
![]() |
B Huppertz The anatomy of the normal placenta J. Clin. Pathol., December 1, 2008; 61(12): 1296 - 1302. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Nakashima, A. Shiozaki, S. Myojo, M. Ito, M. Tatematsu, M. Sakai, Y. Takamori, K. Ogawa, K. Nagata, and S. Saito Granulysin Produced by Uterine Natural Killer Cells Induces Apoptosis of Extravillous Trophoblasts in Spontaneous Abortion Am. J. Pathol., September 1, 2008; 173(3): 653 - 664. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. B. Ness, J. Zhang, D. Bass, and M. A. Klebanoff Interactions between Smoking and Weight in Pregnancies Complicated by Preeclampsia and Small-for-Gestational-Age Birth Am. J. Epidemiol., August 15, 2008; 168(4): 427 - 433. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Detmar, M. Y. Rennie, K. J. Whiteley, D. Qu, Y. Taniuchi, X. Shang, R. F. Casper, S. L. Adamson, J. G. Sled, and A. Jurisicova Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E519 - E530. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-T. Vinnars, L. C.D. Wijnaendts, M. Westgren, A. C. Bolte, N. Papadogiannakis, and J. Nasiell Severe Preeclampsia With and Without HELLP Differ With Regard to Placental Pathology Hypertension, May 1, 2008; 51(5): 1295 - 1299. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. S. Hoffmann, C. J. Weydert, E. Lazartigues, W. J. Kutschke, M. F. Kienzle, J. E. Leach, J. A. Sharma, R. V. Sharma, and R. L. Davisson Chronic Tempol Prevents Hypertension, Proteinuria, and Poor Feto-Placental Outcomes in BPH/5 Mouse Model of Preeclampsia Hypertension, April 1, 2008; 51(4): 1058 - 1065. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Nicola, A. Chirpac, P. K. Lala, and C. Chakraborty Roles of Rho Guanosine 5'-Triphosphatase A, Rho Kinases, and Extracellular Signal Regulated Kinase (1/2) in Prostaglandin E2-Mediated Migration of First-Trimester Human Extravillous Trophoblast Endocrinology, March 1, 2008; 149(3): 1243 - 1251. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Handschuh, J. Guibourdenche, V. Tsatsaris, M. Guesnon, I. Laurendeau, D. Evain-Brion, and T. Fournier Human Chorionic Gonadotropin Produced by the Invasive Trophoblast But Not the Villous Trophoblast Promotes Cell Invasion and Is Down-Regulated by Peroxisome Proliferator-Activated Receptor-{gamma} Endocrinology, October 1, 2007; 148(10): 5011 - 5019. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Minas, U. Jeschke, S.N. Kalantaridou, D.U. Richter, T. Reimer, I. Mylonas, K. Friese, and A. Makrigiannakis Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin Mol. Hum. Reprod., September 1, 2007; 13(9): 663 - 673. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Catov, L. M. Bodnar, R. B. Ness, N. Markovic, and J. M. Roberts Association of Periconceptional Multivitamin Use and Risk of Preterm or Small-for-Gestational-Age Births Am. J. Epidemiol., August 1, 2007; 166(3): 296 - 303. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. J. Keogh, L. K. Harris, A. Freeman, P. N. Baker, J. D. Aplin, G. StJ. Whitley, and J. E. Cartwright Fetal-Derived Trophoblast Use the Apoptotic Cytokine Tumor Necrosis Factor-{alpha}-Related Apoptosis-Inducing Ligand to Induce Smooth Muscle Cell Death Circ. Res., March 30, 2007; 100(6): 834 - 841. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. D. Winn, R. Haimov-Kochman, A. C. Paquet, Y. J. Yang, M. S. Madhusudhan, M. Gormley, K.-T. V. Feng, D. A. Bernlohr, S. McDonagh, L. Pereira, et al. Gene Expression Profiling of the Human Maternal-Fetal Interface Reveals Dramatic Changes between Midgestation and Term Endocrinology, March 1, 2007; 148(3): 1059 - 1079. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.P. Johnson, E. Fitzpatrick, T.D. Dyer, J.B.M. Jowett, S.P. Brennecke, J. Blangero, and E.K. Moses Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach Mol. Hum. Reprod., January 1, 2007; 13(1): 61 - 67. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. T. Chelbi, F. Mondon, H. Jammes, C. Buffat, T.-M. Mignot, J. Tost, F. Busato, I. Gut, R. Rebourcet, P. Laissue, et al. Expressional and Epigenetic Alterations of Placental Serine Protease Inhibitors: SERPINA3 Is a Potential Marker of Preeclampsia Hypertension, January 1, 2007; 49(1): 76 - 83. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Dokras, D. S. Hoffmann, J. S. Eastvold, M. F. Kienzle, L. M. Gruman, P. A. Kirby, R. M. Weiss, and R. L. Davisson Severe Feto-Placental Abnormalities Precede the Onset of Hypertension and Proteinuria in a Mouse Model of Preeclampsia Biol Reprod, December 1, 2006; 75(6): 899 - 907. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-S. N. Siu, M.-Y. Choy, T.-N. Leung, and T.-K. Lau Lack of Site-Specific Production of Decidual Alpha-2 Macroglobulin in Human Pregnancy Reproductive Sciences, October 1, 2006; 13(7): 491 - 496. [Abstract] [PDF] |
||||
![]() |
D. P. Hewitt, P. J. Mark, A. M. Dharmarajan, and B. J. Waddell Placental Expression of Secreted Frizzled Related Protein-4 in the Rat and the Impact of Glucocorticoid-Induced Fetal and Placental Growth Restriction Biol Reprod, July 1, 2006; 75(1): 75 - 81. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.C. Shih, C.L. Chien, H.N. Ho, W.C. Lee, and F.J. Hsieh Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy Hum. Reprod., May 1, 2006; 21(5): 1299 - 1304. [Abstract] [Full Text] [PDF] |
||||
![]() |
P.A. Elustondo, G.E. Hannigan, I. Caniggia, and D.J. MacPhee Integrin-Linked Kinase (ILK) Is Highly Expressed in First Trimester Human Chorionic Villi and Regulates Migration of a Human Cytotrophoblast-Derived Cell Line Biol Reprod, May 1, 2006; 74(5): 959 - 968. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Banyasz, S. Szabo, G. Bokodi, A. Vannay, B. Vasarhelyi, A. Szabo, T. Tulassay, and J. Rigo Jr Genetic polymorphisms of vascular endothelial growth factor in severe pre-eclampsia Mol. Hum. Reprod., April 1, 2006; 12(4): 233 - 236. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.R. Hansson, Y. Chen, J. Brodszki, M. Chen, E. Hernandez-Andrade, J.M. Inman, O.A. Kozhich, I. Larsson, K. Marsal, P. Medstrand, et al. Gene expression profiling of human placentas from preeclamptic and normotensive pregnancies Mol. Hum. Reprod., March 1, 2006; 12(3): 169 - 179. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. J. Lockwood, P. Matta, G. Krikun, L. A. Koopman, R. Masch, P. Toti, F. Arcuri, S.-T. J. Huang, E. F. Funai, and F. Schatz Regulation of Monocyte Chemoattractant Protein-1 Expression by Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} in First Trimester Human Decidual Cells: Implications for Preeclampsia Am. J. Pathol., February 1, 2006; 168(2): 445 - 452. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Eghtesady, J. A. Sedgwick, J. L. Schenbeck, C. Lam, J. Lombardi, R. Ferguson, A. Gardner, J. McNamara, and P. Manning Maternal-Fetal Interactions in Fetal Cardiac Surgery Ann. Thorac. Surg., January 1, 2006; 81(1): 249 - 256. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Goldman and E. Shalev Difference in Progesterone-Receptor Isoforms Ratio Between Early and Late First-Trimester Human Trophoblast Is Associated with Differential Cell Invasion and Matrix Metalloproteinase 2 Expression Biol Reprod, January 1, 2006; 74(1): 13 - 22. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. P. Hewitt, P. J. Mark, and B. J. Waddell Placental Expression of Peroxisome Proliferator-Activated Receptors in Rat Pregnancy and the Effect of Increased Glucocorticoid Exposure Biol Reprod, January 1, 2006; 74(1): 23 - 28. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. L. Straszewski-Chavez, V. M. Abrahams, and G. Mor The Role of Apoptosis in the Regulation of Trophoblast Survival and Differentiation during Pregnancy Endocr. Rev., December 1, 2005; 26(7): 877 - 897. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Sato, H. Fujiwara, B.-X. Zeng, T. Higuchi, S. Yoshioka, and S. Fujii Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries Blood, July 15, 2005; 106(2): 428 - 435. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Soleymanlou, I. Jurisica, O. Nevo, F. Ietta, X. Zhang, S. Zamudio, M. Post, and I. Caniggia Molecular Evidence of Placental Hypoxia in Preeclampsia J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4299 - 4308. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Mondon, T.-M. Mignot, R. Rebourcet, H. Jammes, J.-L. Danan, F. Ferre, and D. Vaiman Profiling of oxygen-modulated gene expression in early human placenta by systematic sequencing of suppressive subtractive hybridization products Physiol Genomics, June 16, 2005; 22(1): 99 - 107. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Takimoto-Ohnishi, T. Saito, J. Ishida, J. Ohnishi, F. Sugiyama, K.-I. Yagami, and A. Fukamizu Differential Roles of Renin and Angiotensinogen in the Feto-Maternal Interface in the Development of Complications of Pregnancy Mol. Endocrinol., May 1, 2005; 19(5): 1361 - 1372. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-C. Lacroix, J. Guibourdenche, T. Fournier, I. Laurendeau, A. Igout, V. Goffin, J. Pantel, V. Tsatsaris, and D. Evain-Brion Stimulation of Human Trophoblast Invasion by Placental Growth Hormone Endocrinology, May 1, 2005; 146(5): 2434 - 2444. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Qiu, M. Yang, B. K. Tsang, and A. Gruslin Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration Mol. Hum. Reprod., September 1, 2004; 10(9): 677 - 684. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |