HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 69/2/373    most recent biolreprod.103.015719v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Escalier, D. Search for Related Content PubMed PubMed Citation Articles by Escalier, D. Agricola Articles by Escalier, D.

New Insights into the Assembly of the Periaxonemal Structures in Mammalian Spermatozoa

Histologie Fonctionnelle et Moléculaire, Université Paris 5, 75270 Paris Cedex 6, France

Disruption of Ube2b in the mouse has revealed that the regular and symmetric organization of the fibrous sheath of the sperm flagella is dependent on expression of the ubiquitin-conjugating enzyme UBE2B. These data could cast light on how a component of the ubiquitin-proteasome pathway participates in the assembly of flagellar periaxonemal structures. Data in the literature support the notion of involvement of ubiquitin-proteasome pathways in the assembly of cytoskeletal components in somatic cells. This review attempts to integrate recent knowledge regarding flagellar components that could be related to proteasome components and, therefore, could be targets of UBE2B in the spermatid. An attempt is made to characterize the human flagellar anomalies of infertile patients, which are the closest to those of Ube2b-deficient mice. These new insights regarding the assembly of mammalian sperm flagella provide a basis for studying the ontogenesis of flagellar accessory structures and suggest leads for medical and genetic investigations.

¹ Correspondence: Denise Escalier, Histologie Fonctionnelle et Moléculaire, Université Paris 5, 45, rue des Saints Pères, 75270 Paris Cedex 6, France. FAX: 33 (0)1 42 86 20 84; denise.escalier{at}biomedicale.univ-paris5.fr

This article has been cited by other articles:

				S. Brunner, D. Colman, A. J. Travis, U. F.O. Luhmann, W. Shi, S. Feil, C. Imsand, J. Nelson, C. Grimm, T. Rulicke, et al. Overexpression of RPGR Leads to Male Infertility in Mice Due to Defects in Flagellar Assembly Biol Reprod, October 1, 2008; 79(4): 608 - 617. [Abstract] [Full Text] [PDF]

				S. Absalon, T. Blisnick, L. Kohl, G. Toutirais, G. Dore, D. Julkowska, A. Tavenet, and P. Bastin Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes Mol. Biol. Cell, March 1, 2008; 19(3): 929 - 944. [Abstract] [Full Text] [PDF]

				M. W. Tengowski, D. Feng, M. Sutovsky, and P. Sutovsky Differential Expression of Genes Encoding Constitutive and Inducible 20S Proteasomal Core Subunits in the Testis and Epididymis of Theophylline- or 1,3-Dinitrobenzene-Exposed Rats Biol Reprod, January 1, 2007; 76(1): 149 - 163. [Abstract] [Full Text] [PDF]

				V. Mitchell, N. Rives, M. Albert, M.-C. Peers, J. Selva, B. Clavier, E. Escudier, and D. Escalier Outcome of ICSI with ejaculated spermatozoa in a series of men with distinct ultrastructural flagellar abnormalities Hum. Reprod., August 1, 2006; 21(8): 2065 - 2074. [Abstract] [Full Text] [PDF]

				D. Escalier Knockout mouse models of sperm flagellum anomalies Hum. Reprod. Update, July 1, 2006; 12(4): 449 - 461. [Abstract] [Full Text] [PDF]

				K A Fischer, K Van Leyen, K W Lovercamp, G Manandhar, M Sutovsky, D Feng, T Safranski, and P Sutovsky 15-Lipoxygenase is a component of the mammalian sperm cytoplasmic droplet Reproduction, August 1, 2005; 130(2): 213 - 222. [Abstract] [Full Text] [PDF]

				J. Kwon, Y.-L. Wang, R. Setsuie, S. Sekiguchi, M. Sakurai, Y. Sato, W.-W. Lee, Y. Ishii, S. Kyuwa, M. Noda, et al. Developmental Regulation of Ubiquitin C-Terminal Hydrolase Isozyme Expression During Spermatogenesis in Mice Biol Reprod, August 1, 2004; 71(2): 515 - 521. [Abstract] [Full Text] [PDF]