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BOR - Papers in Press, published online ahead of print April 2, 2003.
Biol Reprod 2003, 10.1095/biolreprod.102.013821
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BIOLOGY OF REPRODUCTION 69, 398–403 (2003)
DOI: 10.1095/biolreprod.102.013821
© 2003 by the Society for the Study of Reproduction, Inc.

Ovary

Chronic Treatment with an Agonist of Gonadotropin-Releasing Hormone Enhances Luteal Function in Cattle1 ,2

T.L. Davis3,6,7, M.L. Mussard4,6,7, H. Jimenez-Severiano5,6, W.J. Enright8, and J.E. Kinder2,6,7

Department of Animal Sciences,6 University of Nebraska, Lincoln, Nebraska 68583-0908 Department of Animal Sciences,7 Ohio State University, Columbus, Ohio 43210-1095 Intervet International,8 5830 AA Boxmeer, The Netherlands

Our hypothesis was that luteal function, as determined by plasma progesterone concentrations, and corpus luteum (CL) size is enhanced in cattle administered an agonist of GnRH when the CL is developing as compared with administration of an agonist when the CL is fully functional. Cattle were chronically administered a GnRH agonist, azagly-nafarelin, from Day 3 to Day 21 (D3) or Day 12 to Day 21 (D12) or served as untreated control females (Day 0 = behavioral estrus). Blood samples were serially collected on Days 7 and 14 to evaluate LH secretory patterns and twice daily to measure plasma progesterone. Ultrasonographic examinations were conducted daily to record the area of the CL. CL size and plasma progesterone concentrations were both enhanced in the D3 group as compared with the control group. Progesterone was increased in the D12 group on Days 16 and 17 as compared with the control females. Treatment with GnRH agonist increased basal and mean LH concentrations in both D3 and D12 groups as compared with the controls. We rejected our hypothesis because chronic administration of a GnRH agonist increased plasma progesterone when administered both when the CL was developing and when it was fully functional. The enhanced luteal function was likely due to increased basal LH.

1 This research was supported by USDA Animal Health Formula Funding to the University of Nebraska.

2 Correspondence: James E. Kinder, 110B Animal Science, 2029 Fyffe Rd., Ohio State University, Columbus, OH 43210-1095. FAX: 614 292 2929; kinder.15{at}osu.edu

3 Current address: Department of Animal Sciences, 207 Gerlaugh Hall, 1680 Madison Ave., OARDC, Wooster, OH 44691-4096

4 Current address: Department of Animal Sciences, Ohio State University, 3638 Kays Ave., Dublin, OH 43017.

5 Current address: CENID Fisiologia y Mejoramiento Animal, INIFAP-SAGARPA, Apdo. Postal 2-29, Queretaro, Queretaro, Mexico






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