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BOR - Papers in Press, published online ahead of print July 9, 2003.
Biol Reprod 2003, 10.1095/biolreprod.103.019877
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BIOLOGY OF REPRODUCTION 69, 1615–1625 (2003)
DOI: 10.1095/biolreprod.103.019877
© 2003 by the Society for the Study of Reproduction, Inc.

Gamete Biology

Toward the Genetics of Mammalian Reproduction: Induction and Mapping of Gametogenesis Mutants in Mice1

Jeremy O. Ward, Laura G. Reinholdt, Suzanne A. Hartford, Lawriston A. Wilson, Robert J. Munroe, Kerry J. Schimenti, Brian J. Libby, Marilyn O'Brien, Janice K. Pendola, John Eppig, and John C. Schimenti2

The Jackson Laboratory, Bar Harbor, Maine 04609

The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility. To further the discovery of genes required for mammalian gametogenesis, phenotype-driven screens were performed in mice using random chemical mutagenesis of whole animals and embryonic stem cells. Eleven initial mutations are reported here that affect proliferation of germ cells, meiosis, spermiogenesis, and spermiation. Nine of the mutations have been mapped genetically. These preliminary studies provide baselines for estimating the number of genes required for gametogenesis and offer guidance in conducting new genetic screens that will accelerate and optimize mutant discovery. This report demonstrates the efficacy and expediency of mutagenesis to identify new genes required for mammalian gamete development.

1 Supported by NIH grant GM45415 to J.S. J.O.W. and L.G.R. were supported by NRSA awards GM64275-01A and GM66650-01, respectively. A Cancer Center Grant (CA34196) to The Jackson Laboratory supported core facilities used in this work.

2 Correspondence: FAX: 207 288 6082; jcs{at}jax.org




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