Biol Reprod
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print July 30, 2003.
Biol Reprod 2003, 10.1095/biolreprod.103.019745
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
69/6/1771    most recent
biolreprod.103.019745v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Petersen, S. L.
Right arrow Articles by Carpenter, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Petersen, S. L.
Right arrow Articles by Carpenter, C. D.
Agricola
Right arrow Articles by Petersen, S. L.
Right arrow Articles by Carpenter, C. D.
BIOLOGY OF REPRODUCTION 69, 1771–1778 (2003)
DOI: 10.1095/biolreprod.103.019745
© 2003 by the Society for the Study of Reproduction, Inc.

Minireview

Direct and Indirect Regulation of Gonadotropin-Releasing Hormone Neurons by Estradiol1

Sandra L. Petersen2, Erich N. Ottem, and Clifford D. Carpenter

Department of Biology, Neuroscience and Behavior Graduate Program, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, Massachusetts 01003

Estrogen signaling to GnRH neurons is critical for coordinating the preovulatory surge release of LH with follicular maturation. Until recently it was thought that estrogen signaled GnRH neurons only indirectly through numerous afferent systems. This minireview presents new evidence indicating that GnRH neurons are directly regulated by estradiol (E2), primarily through estrogen receptor (ER)-ß, and indirectly through E2-sensitive neurons in the anteroventral periventricular (AVPV) region. The data described suggest that E2 generally represses GnRH gene expression but that this repression is transiently overcome by indirect E2-dependent signals relayed by AVPV neurons. We also present evidence that the AVPV neurons responsible for relaying E2 signals to GnRH neurons are multifunctional gamma aminobutyric acid-ergic/glutamatergic/neuropeptidergic neurons.

1 This work was supported by NIH grant HD27305 to S.L.P.

2 Correspondence: Sandra L. Petersen, Department of Biology, 611 North Pleasant St., Morrill Science Center II-South, University of Massachusetts, Amherst, MA 01003. FAX: 413 545 3243; sandyp{at}bio.umass.edu




This article has been cited by other articles:


Home page
 EndocrinologyHome page
E. M. Gibson, S. A. Humber, S. Jain, W. P. Williams III, S. Zhao, G. E. Bentley, K. Tsutsui, and L. J. Kriegsfeld
Alterations in RFamide-Related Peptide Expression Are Coordinated with the Preovulatory Luteinizing Hormone Surge
Endocrinology, October 1, 2008; 149(10): 4958 - 4969.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Clarkson, X. d'Anglemont de Tassigny, A. S. Moreno, W. H. Colledge, and A. E. Herbison
Kisspeptin-GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge
J. Neurosci., August 27, 2008; 28(35): 8691 - 8697.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. E. Ottowitz, D. D. Dougherty, A. J. Fischman, and J. E. Hall
[18F]2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Demonstration of Estrogen Negative and Positive Feedback on Luteinizing Hormone Secretion in Women
J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3208 - 3214.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Gonzalez-Martinez, C. De Mees, Q. Douhard, C. Szpirer, and J. Bakker
Absence of Gonadotropin-Releasing Hormone 1 and Kiss1 Activation in {alpha}-Fetoprotein Knockout Mice: Prenatal Estrogens Defeminize the Potential to Show Preovulatory Luteinizing Hormone Surges
Endocrinology, May 1, 2008; 149(5): 2333 - 2340.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Pielecka-Fortuna, Z. Chu, and S. M. Moenter
Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol
Endocrinology, April 1, 2008; 149(4): 1979 - 1986.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. Nishimura, K. Ui-Tei, K. Saigo, H. Ishii, Y. Sakuma, and M. Kato
17{beta}-Estradiol at Physiological Concentrations Augments Ca2+-Activated K+ Currents via Estrogen Receptor {beta} in the Gonadotropin-Releasing Hormone Neuronal Cell Line GT1-7
Endocrinology, February 1, 2008; 149(2): 774 - 782.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. N. Karatsoreos and R. Silver
Minireview: The Neuroendocrinology of the Suprachiasmatic Nucleus as a Conductor of Body Time in Mammals
Endocrinology, December 1, 2007; 148(12): 5640 - 5647.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. Arreguin-Arevalo, T. L. Davis, and T. M. Nett
Differential Modulation of Gonadotropin Secretion by Selective Estrogen Receptor 1 and Estrogen Receptor 2 Agonists in Ovariectomized Ewes
Biol Reprod, August 1, 2007; 77(2): 320 - 328.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Hrabovszky, I. Kallo, N. Szlavik, E. Keller, I. Merchenthaler, and Z. Liposits
Gonadotropin-Releasing Hormone Neurons Express Estrogen Receptor-{beta}
J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2827 - 2830.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. S. Kauffman, M. L. Gottsch, J. Roa, A. C. Byquist, A. Crown, D. K. Clifton, G. E. Hoffman, R. A. Steiner, and M. Tena-Sempere
Sexual Differentiation of Kiss1 Gene Expression in the Brain of the Rat
Endocrinology, April 1, 2007; 148(4): 1774 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. T. Smith, S. M. Popa, D. K. Clifton, G. E. Hoffman, and R. A. Steiner
Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge.
J. Neurosci., June 21, 2006; 26(25): 6687 - 6694.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. L. Petersen, S. Krishnan, and E. D. Hudgens
The Aryl Hydrocarbon Receptor Pathway and Sexual Differentiation of Neuroendocrine Functions
Endocrinology, June 1, 2006; 147(6): s33 - s42.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. R. Pak, W. C. J. Chung, J. L. Roberts, and R. J. Handa
Ligand-Independent Effects of Estrogen Receptor {beta} on Mouse Gonadotropin-Releasing Hormone Promoter Activity
Endocrinology, April 1, 2006; 147(4): 1924 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J Christoffel, G Rimoldi, and W Wuttke
Effects of 8-prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3-month treatment.
J. Endocrinol., March 1, 2006; 188(3): 397 - 405.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. O. de la Iglesia and W. J. Schwartz
Minireview: Timely Ovulation: Circadian Regulation of the Female Hypothalamo-Pituitary-Gonadal Axis
Endocrinology, March 1, 2006; 147(3): 1148 - 1153.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. J. Kriegsfeld, D. F. Mei, G. E. Bentley, T. Ubuka, A. O. Mason, K. Inoue, K. Ukena, K. Tsutsui, and R. Silver
Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
PNAS, February 14, 2006; 103(7): 2410 - 2415.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. M. Khan, M. Hadman, C. Wakade, L. M. De Sevilla, K. M. Dhandapani, V. B. Mahesh, R. K. Vadlamudi, and D. W. Brann
Cloning, Expression, and Localization of MNAR/PELP1 in Rodent Brain: Colocalization in Estrogen Receptor-{alpha}- But Not in Gonadotropin-Releasing Hormone-Positive Neurons
Endocrinology, December 1, 2005; 146(12): 5215 - 5227.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A.L. Filby and C.R. Tyler
Molecular Characterization of Estrogen Receptors 1, 2a, and 2b and Their Tissue and Ontogenic Expression Profiles in Fathead Minnow (Pimephales promelas)
Biol Reprod, October 1, 2005; 73(4): 648 - 662.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. T. Smith, M. J. Cunningham, E. F. Rissman, D. K Clifton, and R. A. Steiner
Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse
Endocrinology, September 1, 2005; 146(9): 3686 - 3692.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. T. Smith, H. M. Dungan, E. A. Stoll, M. L. Gottsch, R. E. Braun, S. M. Eacker, D. K Clifton, and R. A. Steiner
Differential Regulation of KiSS-1 mRNA Expression by Sex Steroids in the Brain of the Male Mouse
Endocrinology, July 1, 2005; 146(7): 2976 - 2984.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. E. Campbell, S.-K. Han, and A. E. Herbison
Biocytin Filling of Adult Gonadotropin-Releasing Hormone Neurons in Situ Reveals Extensive, Spiny, Dendritic Processes
Endocrinology, March 1, 2005; 146(3): 1163 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C M Gomes, C Raineki, P R. de Paula, G S Severino, C V V Helena, J A Anselmo-Franci, C R Franci, G L Sanvitto, and A B Lucion
Neonatal handling and reproductive function in female rats
J. Endocrinol., February 1, 2005; 184(2): 435 - 445.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. N. Ottem, J. G. Godwin, S. Krishnan, and S. L. Petersen
Dual-Phenotype GABA/Glutamate Neurons in Adult Preoptic Area: Sexual Dimorphism and Function
J. Neurosci., September 15, 2004; 24(37): 8097 - 8105.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. L. Gottsch, M. J. Cunningham, J. T. Smith, S. M. Popa, B. V. Acohido, W. F. Crowley, S. Seminara, D. K. Clifton, and R. A. Steiner
A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse
Endocrinology, September 1, 2004; 145(9): 4073 - 4077.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. L. Temple, E. Laing, A. Sunder, and S. Wray
Direct Action of Estradiol on Gonadotropin-Releasing Hormone-1 Neuronal Activity via a Transcription-Dependent Mechanism
J. Neurosci., July 14, 2004; 24(28): 6326 - 6333.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Society for the Study of Reproduction.