| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Minireview |
State Key Laboratory of Reproductive Biology,3 Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P. R. China
Department of Molecular Biology,4 University of Texas Southwestern Medical Center, Dallas, Texas 75390
Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases that are widely distributed in eukaryotic cells. Studies in the last decade revealed that MAPK cascade plays pivotal roles in regulating the meiotic cell cycle progression of oocytes. In mammalian species, activation of MAPK in cumulus cells is necessary for gonadotropin-induced meiotic resumption of oocytes, while MAPK activation is not required for spontaneous meiotic resumption. After germinal vesicle breakdown (GVBD), MAPK is involved in the regulation of microtubule organization and meiotic spindle assembly. The activation of this kinase is essential for the maintenance of metaphase II arrest, while its inactivation is a prerequisite for pronuclear formation after fertilization or parthenogenetic activation. MAPK cascade interacts extensively with other protein kinases such as maturation-promoting factor, protein kinase A, protein kinase C, and calmodulin-dependent protein kinase II, as well as with protein phosphatases in oocyte meiotic cell cycle regulation. The cross talk between MAPK cascade and other protein kinases is discussed. The review also addresses unsolved problems and discusses future directions.
2 Correspondence: FAX: 8610-6256-5689; sunqy1{at}yahoo.com
This article has been cited by other articles:
|
|
 |
|
  Y.-L. Miao, K. Kikuchi, Q.-Y. Sun, and H. Schatten Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility Hum. Reprod. Update, May 8, 2009; (2009) dmp014v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Li, H. Schatten, and Q.-Y. Sun Androgen receptor's destiny in mammalian oocytes: a new hypothesis Mol. Hum. Reprod., March 1, 2009; 15(3): 149 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Tharasanit, S Colleoni, C Galli, B Colenbrander, and T A E Stout Protective effects of the cumulus-corona radiata complex during vitrification of horse oocytes Reproduction, March 1, 2009; 137(3): 391 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-H. Kim, E.-Y. Kim, and K.-A. Lee SEBOX Is Essential for Early Embryogenesis at the Two-Cell Stage in the Mouse Biol Reprod, December 1, 2008; 79(6): 1192 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Li, J.-S. Ai, B.-Z. Xu, B. Xiong, S. Yin, S.-L. Lin, Y. Hou, D.-Y. Chen, H. Schatten, and Q.-Y. Sun Testosterone Potentially Triggers Meiotic Resumption by Activation of Intra-Oocyte SRC and MAPK in Porcine Oocytes Biol Reprod, November 1, 2008; 79(5): 897 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Swain and T. B. Pool ART failure: oocyte contributions to unsuccessful fertilization Hum. Reprod. Update, September 1, 2008; 14(5): 431 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Fan, M. Shimada, Z. Liu, N. Cahill, N. Noma, Y. Wu, J. Gossen, and J. S. Richards Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation Development, June 15, 2008; 135(12): 2127 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cecconi, A. Mauro, G. Capacchietti, P. Berardinelli, N. Bernabo, A. R. Di Vincenzo, M. Mattioli, and B. Barboni Meiotic Maturation of Incompetent Prepubertal Sheep Oocytes Is Induced by Paracrine Factor(s) Released by Gonadotropin-Stimulated Oocyte-Cumulus Cell Complexes and Involves Mitogen-Activated Protein Kinase Activation Endocrinology, January 1, 2008; 149(1): 100 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-H. Lee, M. Ohmachi, S. Arur, S. Nayak, R. Francis, D. Church, E. Lambie, and T. Schedl Multiple Functions and Dynamic Activation of MPK-1 Extracellular Signal-Regulated Kinase Signaling in Caenorhabditis elegans Germline Development Genetics, December 1, 2007; 177(4): 2039 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-G. Liang, Y.-Q. Su, H.-Y. Fan, H. Schatten, and Q.-Y. Sun Mechanisms Regulating Oocyte Meiotic Resumption: Roles of Mitogen-Activated Protein Kinase Mol. Endocrinol., September 1, 2007; 21(9): 2037 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Wayne, H.-Y. Fan, X. Cheng, and J. S. Richards Follicle-Stimulating Hormone Induces Multiple Signaling Cascades: Evidence that Activation of Rous Sarcoma Oncogene, RAS, and the Epidermal Growth Factor Receptor Are Critical for Granulosa Cell Differentiation Mol. Endocrinol., August 1, 2007; 21(8): 1940 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Matsubara, I. Kawasaki, S. Urushiyama, T. Yasuda, M. Shirakata, Y. Iino, H. Shibuya, and Y. Yamanashi The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans Genes Cells, March 1, 2007; 12(3): 407 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Tharasanit, S Colleoni, G Lazzari, B Colenbrander, C Galli, and T A E Stout Effect of cumulus morphology and maturation stage on the cryopreservability of equine oocytes. Reproduction, November 1, 2006; 132(5): 759 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Rossi, G. Macchiarelli, M.G. Palmerini, R. Canipari, and S. Cecconi Meiotic spindle configuration is differentially influenced by FSH and epidermal growth factor during in vitro maturation of mouse oocytes Hum. Reprod., July 1, 2006; 21(7): 1765 - 1770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nganvongpanit, H. Muller, F. Rings, M. Hoelker, D. Jennen, E. Tholen, V. Havlicek, U. Besenfelder, K. Schellander, and D. Tesfaye Selective degradation of maternal and embryonic transcripts in in vitro produced bovine oocytes and embryos using sequence specific double-stranded RNA. Reproduction, May 1, 2006; 131(5): 861 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tatone, M. C. Carbone, R. Gallo, S. Delle Monache, M. Di Cola, E. Alesse, and F. Amicarelli Age-Associated Changes in Mouse Oocytes During Postovulatory In Vitro Culture: Possible Role for Meiotic Kinases and Survival Factor BCL2 Biol Reprod, February 1, 2006; 74(2): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M.H. Combelles, R. A. Fissore, D. F. Albertini, and C. Racowsky In vitro maturation of human oocytes and cumulus cells using a co-culture three-dimensional collagen gel system Hum. Reprod., May 1, 2005; 20(5): 1349 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Y. Zheng, Q.-Z. Li, D.-Y. Chen, H. Schatten, and Q.-Y. Sun Translocation of phospho-protein kinase Cs implies their roles in meiotic-spindle organization, polar-body emission and nuclear activity in mouse eggs Reproduction, February 1, 2005; 129(2): 229 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ma, D. Zhang, Y. Hou, Y.-H. Li, Q.-Y. Sun, X.-F. Sun, and W.-H. Wang Reduced Expression of MAD2, BCL2, and MAP Kinase Activity in Pig Oocytes after In Vitro Aging Are Associated with Defects in Sister Chromatid Segregation During Meiosis II and Embryo Fragmentation After Activation Biol Reprod, February 1, 2005; 72(2): 373 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ito, N. Kawano, M. Hirabayashi, and M. Shimada The role of calcium/calmodulin-dependent protein kinase II on the inactivation of MAP kinase and p34cdc2 kinase during fertilization and activation in pig oocytes Reproduction, October 1, 2004; 128(4): 409 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-J. Huo, H.-Y. Fan, C.-G. Liang, L.-Z. Yu, Z.-S. Zhong, D.-Y. Chen, and Q.-Y. Sun Regulation of Ubiquitin-Proteasome Pathway on Pig Oocyte Meiotic Maturation and Fertilization Biol Reprod, September 1, 2004; 71(3): 853 - 862. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
