| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Minireview |
Departments of Obstetrics and Gynecology and Biological Chemistry,3 University of Michigan Medical School, Ann Arbor, Michigan 48109
The LH/hCG receptor, a member of the G protein coupled receptor family mediates the cellular actions of LH in the ovary. A considerable amount of information regarding its structure, mechanism of activation, and regulation of expression has emerged in recent years. Here we provide a brief overview of the current information on the structural organization of the receptor and the mechanism of receptor mediated signaling as well as an in-depth discussion on recent developments pertaining to the regulation of receptor expression. Specifically, we describe studies from our laboratory showing that the posttranscriptional regulation of the receptor involves an LH/hCG receptor mRNA-binding protein. We also propose a model to explain the loss of steady-state LH/hCG receptor mRNA levels during receptor down-regulation.
2 Correspondence: K.M.J. Menon, 6428 Medical Science I, 1301 Catherine St., Ann Arbor, MI 48109-0617. FAX: 734 936 8617; kmjmenon{at}umich.edu
This article has been cited by other articles:
|
|
 |
|
  E. Dos Santos, M.-N. Dieudonne, M.-C. Leneveu, R. Pecquery, V. Serazin, and Y. Giudicelli In vitro effects of chorionic gonadotropin hormone on human adipose development J. Endocrinol., August 1, 2007; 194(2): 313 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Cameo, M. Szmidt, Z. Strakova, P. Mavrogianis, K. L. Sharpe-Timms, and A. T. Fazleabas Decidualization Regulates the Expression of the Endometrial Chorionic Gonadotropin Receptor in the Primate Biol Reprod, November 1, 2006; 75(5): 681 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Nair, H. Peegel, and K. M. J. Menon The Role of Luteinizing Hormone/Human Chorionic Gonadotropin Receptor-Specific mRNA Binding Protein in Regulating Receptor Expression in Human Ovarian Granulosa Cells J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2239 - 2243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ascoli Learning New Tricks from an Old Dog: The Processing of the Intracellular Precursor of the Luteinizing Hormone Receptor (LHR) into the Mature Cell-Surface LHR Is a Regulated Process Endocrinology, August 1, 2005; 146(8): 3221 - 3223. [Full Text] [PDF]
|
|
|
|
|
|
N. H. Ing Steroid Hormones Regulate Gene Expression Posttranscriptionally by Altering the Stabilities of Messenger RNAs Biol Reprod, June 1, 2005; 72(6): 1290 - 1296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-F. Kwok, W.-K. So, Y. Wang, and W. Ge Zebrafish Gonadotropins and Their Receptors: I. Cloning and Characterization of Zebrafish Follicle-Stimulating Hormone and Luteinizing Hormone Receptors-- Evidence for Their Distinct Functions in Follicle Development Biol Reprod, June 1, 2005; 72(6): 1370 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. M. Munshi, C. L. Clouser, H. Peegel, and K. M. J. Menon Evidence that Palmitoylation of Carboxyl Terminus Cysteine Residues of the Human Luteinizing Hormone Receptor Regulates Postendocytic Processing Mol. Endocrinol., March 1, 2005; 19(3): 749 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang and K. M. J. Menon Regulation of Luteinizing Hormone/Chorionic Gonadotropin Receptor Messenger Ribonucleic Acid Expression in the Rat Ovary: Relationship to Cholesterol Metabolism Endocrinology, January 1, 2005; 146(1): 423 - 431. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
