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A Morphological and Immunohistochemical Comparison of Mammary Tissues from the Short-Tailed Fruit Bat (Carollia perspicillata) and the Mouse¹

Laboratory of Genetics and Physiology,³ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Department of Obstetrics and Gynecology,⁴ SUNY Downstate Medical Center, New York, New York 11203 Department of Molecular Genetics,⁵ University of Texas M.D. Anderson Cancer Center, Houston, Texas 77530

In the present study, mammary tissues from the fruit bat (Carollia perspicillata) and mouse (Mus musculus) were compared using histological and immunohistochemical methods. Because the female bat exhibits greater reproductive similarities to humans, it might provide a useful animal model for studying mammary physiology and disease with relevance to our own species. In lactating and recently lactating specimens, bat tissue had significantly fewer adipocytes and more collagenous connective tissue compared to the mouse. The proteins Stat5a, keratin 5, Npt2b, and E-cadherin were all similarly localized in mouse and bat mammary tissues taken from lactating animals. The present study demonstrates that whereas the epithelial compartment and the presence of differentiation markers are conserved between the mouse and bat, differences exist in the stromal compartment.

¹ Supported by a grant from the National Science Foundation, IBN- 0220458, to R.R.B.

² Correspondence: Gertraud Robinson, Laboratory of Genetics and Physiology, NIDDK, NIH, Building 8, Room 101, Bethesda, MD 20892-0822. FAX: 301 480 7312; traudl{at}nih.gov

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