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BOR - Papers in Press, published online ahead of print January 28, 2004.
Biol Reprod 2004, 10.1095/biolreprod.103.022616
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BIOLOGY OF REPRODUCTION 70, 1589–1593 (2004)
DOI: 10.1095/biolreprod.103.022616
© 2004 by the Society for the Study of Reproduction, Inc.

Reproductive Technology

Telomere Lengths in Cloned Transgenic Pigs1

Le Jiang3, D. Bart Carter5, Jie Xu3, Xiangzhong Yang3, Randall S. Prather4, and X. Cindy Tian2,3

Department of Animal Science and Center for Regenerative Biology,3 University of Connecticut, Storrs, Connecticut 06269 Department of Animal Science4 and Department of Veterinary Pathobiology,5 University of Missouri-Columbia, Columbia, Missouri 65211

Studies of cloned cattle and mice have resulted in controversies regarding the restoration of eroded telomere length of donor cells by the nuclear transfer process. Little is known about telomere lengths in pigs from either natural reproduction or nuclear transfer. In this study, we measured the telomere lengths in six major porcine organs from animals of different ages, and found that their lengths remained consistent throughout different tissues during fetal stages, and then shortened, in a tissue- specific manner, after birth. Telomeres of skin samples from six cloned transgenic pigs at 4 mo of age did not differ significantly from those of age-matched controls. Two cloned pigs that died shortly after birth had skin telomere lengths equivalent to those of late-stage fetuses.

1 Supported by funding from Connecticut Innovations, Inc., to X.Y. and National Institutes of Health (R01 RR13438) to R.S.P.

2 Correspondence: X. Cindy Tian, 1392 Storrs Road, Storrs, CT 06269- 4243. FAX: 860 486 8809, xtian{at}canr.uconn.edu




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Copyright © 2004 by the Society for the Study of Reproduction.