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BOR - Papers in Press, published online ahead of print February 6, 2004.
Biol Reprod 2004, 10.1095/biolreprod.103.025668
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BIOLOGY OF REPRODUCTION 70, 1731–1737 (2004)
DOI: 10.1095/biolreprod.103.025668
© 2004 by the Society for the Study of Reproduction, Inc.

Testis

Regulation of Mouse Spermatogonial Stem Cell Self-Renewing Divisionby the Pituitary Gland1

Mito Kanatsu-Shinohara3, Takeshi Morimoto4, Shinya Toyokuni5, and Takashi Shinohara2,3

Horizontal Medical Research Organization,3 Department of Clinical Epidemiology,4 Department of Pathologyand Biology of Diseases,5 Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan

Spermatogenesis originates in spermatogonial stem cells, which have the unique mode of replication. It is considered that a single stem cell can produce two stem cells (self-renewing division), one stem and one differentiating (asymmetric division), or two differentiating cells (differentiating division). However, little is known regarding how each type of division is regulated. In this investigation, we focused on the analysis of self- renewing division and examined the effect of the pituitary gland using two models of stem cell self-renewing division. In the first experiment using newborn mice, the administration of GnRH- analogue, which represses the release of gonadotropin, reduced the number of stem cells during postnatal testicular development, suggesting that the pituitary gland enhances stem cell self- renewing division. In the second experiment, however, the number of stem cells increased dramatically in hypophysectomized adult recipients after spermatogonial transplantation. Thus, the pituitary gland affects the self-renewing division of stem cells, but these contradictory results suggest that its role may be different depending on the stage of the testicular development.

1 M.K.-S. was supported by a grant from the Japan Society for the Promotion of Science. Financial support for this research was provided by the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

2 Correspondence: Takashi Shinohara, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan. FAX: 81 75 753 9306;takashi{at}mfour.med.kyoto-u.ac.jp




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