Biol Reprod Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print June 30, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.030627
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
71/5/1491    most recent
biolreprod.104.030627v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vidal, B.
Right arrow Articles by Dufour, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vidal, B.
Right arrow Articles by Dufour, S.
Agricola
Right arrow Articles by Vidal, B.
Right arrow Articles by Dufour, S.
BIOLOGY OF REPRODUCTION 71, 1491–1500 (2004)
DOI: 10.1095/biolreprod.104.030627
© 2004 by the Society for the Study of Reproduction, Inc.

Neuroendocrinology

Dopamine Inhibits Luteinizing Hormone Synthesis and Release in the Juvenile European Eel: A Neuroendocrine Lock for the Onset of Puberty1

Bernadette Vidal3, Catherine Pasqualini4, Nadine Le Belle3, M. Claire H. Holland5, Miskal Sbaihi3, Philippe Vernier4, Yonathan Zohar5, and Sylvie Dufour2,3

USM 0401,3 UMR 5178 CNRS/MNHN/UPMC Biologie des Organismes Marins et Ecosystèmes, DMPA, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05, France DEPSN,4 UPR CNRS 2197, Institut de Neurobiologie Alfred Fessard, CNRS, 91198 Gif-sur-Yvette Cedex, France Center of Marine Biotechnology,5 University of Maryland Biotechnology Institute, Baltimore, Maryland 21202

In various adult teleost fishes, LH ovulatory peak is under a dual neurohormonal control that is stimulatory by GnRH and inhibitory by dopamine (DA). We investigated whether DA could also be involved in the inhibitory control of LH at earlier steps of gametogenesis by studying the model of the European eel, Anguilla anguilla, which remains at a prepubertal stage until the oceanic reproductive migration. According to a protocol previously developed in the striped bass, eels received sustained treatments with GnRH agonist (GnRHa), DA-receptor antagonist (pimozide), and testosterone (T) either alone or in combination. Only the triple treatment with T, GnRHa, and pimozide could trigger dramatic increases in LH synthesis and release as well as in plasma vitellogenin levels and a stimulation of ovarian vitellogenesis. Thus, in the prepubertal eel, removal of DA inhibition is required for triggering GnRH-stimulated LH synthesis and release as well as ovarian development. To locate the anatomical support for DA inhibition, the distribution of tyrosine hydroxylase (TH) in the brain and pituitary was studied by immunocytochemistry. Numerous TH-immunoreactive cell bodies were observed in the preoptic anteroventral nucleus, with a dense tract of immunoreactive fibers reaching the pituitary proximal pars distalis, where the gonadotrophs are located. This pathway corresponds to that mediating the inhibition of LH and ovulation in adult teleosts. To our knowledge, this is the first demonstration of a pivotal role for DA in the control of LH and puberty in a juvenile teleost. These data support the view that DA inhibition on LH secretion is an ancient evolutionary component in the neuroendocrine regulation of reproduction that may have been partially maintained throughout vertebrate evolution.

1 Supported in part by research grant 3900 from CNRS, France/NSF, USA (to S.D. and Y.Z.).

2 Correspondence: Sylvie Dufour, USM 0401, UMR 5178 CNRS, DMPA, Muséum National d'Histoire Naturelle, 7 rue Cuvier, 75231 Paris Cedex 05, France. FAX: 33 1 40793618; dufour{at}mnhn.fr




This article has been cited by other articles:


Home page
 EndocrinologyHome page
C. Pasqualini, F.-A. Weltzien, B. Vidal, S. Baloche, C. Rouget, N. Gilles, D. Servent, P. Vernier, and S. Dufour
Two Distinct Dopamine D2 Receptor Genes in the European Eel: Molecular Characterization, Tissue-Specific Transcription, and Regulation by Sex Steroids
Endocrinology, March 1, 2009; 150(3): 1377 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
J. Kulkarni, A. de Castella, P. B. Fitzgerald, C. T. Gurvich, M. Bailey, C. Bartholomeusz, and H. Burger
Estrogen in Severe Mental Illness: A Potential New Treatment Approach
Arch Gen Psychiatry, August 1, 2008; 65(8): 955 - 960.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. L Filby, R. v. Aerle, J. Duitman, and C. R Tyler
The Kisspeptin/Gonadotropin-Releasing Hormone Pathway and Molecular Signaling of Puberty in Fish
Biol Reprod, February 1, 2008; 78(2): 278 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
B. Levavi-Sivan, J. Biran, and E. Fireman
Sex Steroids Are Involved in the Regulation of Gonadotropin-Releasing Hormone and Dopamine D2 Receptors in Female Tilapia Pituitary
Biol Reprod, October 1, 2006; 75(4): 642 - 650.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F.-A. Weltzien, C. Pasqualini, M.-E. Sebert, B. Vidal, N. Le Belle, O. Kah, P. Vernier, and S. Dufour
Androgen-Dependent Stimulation of Brain Dopaminergic Systems in the Female European Eel (Anguilla anguilla)
Endocrinology, June 1, 2006; 147(6): 2964 - 2973.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Society for the Study of Reproduction.