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BOR - Papers in Press, published online ahead of print July 30, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.030932
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BIOLOGY OF REPRODUCTION 71, 1779–1784 (2004)
DOI: 10.1095/biolreprod.104.030932
© 2004 by the Society for the Study of Reproduction, Inc.

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Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternal and Fetal Failures

Emanuela Maioli1, Vittoria Fortino, and Adriana Pacini

Department of Physiology, Section of Immunoendocrinology and Reproductive Physiology, University of Siena, 8-53100 Siena, Italy

Preeclampsia is a disorder associated with pregnancy that affects both the mother and the fetus. Typical features of the disease are maternal hypertension, proteinuria, and edema as well as fetal growth retardation. Although the etiological details are still being debated, a consensus exists that the starting point is deficient placentation in the first half of pregnancy. The crucial early steps are reduced trophoblast invasiveness and enhanced apoptotic death. In the present review, we demonstrate that parathyroid hormone-related protein is involved not only in the maternal and fetal failures but also in the etiological aspects of the disease. We hypothesize that reduced local production of the peptide is a major causative event.

1 Correspondence: Emanuela Maioli, Department of Physiology, Via Aldo Moro, 8-53100 Siena, Italy. FAX: 39 577 234219; maioli{at}unisi.it




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Expression and Biological Activity of Parathyroid Hormone-Related Peptide in Pregnant Rat Uterine Artery: Any Role for 8-Iso-Prostaglandin F2{alpha}?
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[Abstract] [Full Text] [PDF]


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Copyright © 2004 by the Society for the Study of Reproduction.