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BOR - Papers in Press, published online ahead of print September 22, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.031245
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BIOLOGY OF REPRODUCTION 72, 2–13 (2005)
DOI: 10.1095/biolreprod.104.031245
© 2005 by the Society for the Study of Reproduction, Inc.

Centrosome Reduction During Gametogenesis and Its Significance1

Gaurishankar Manandhar2,3, Heide Schatten5, and Peter Sutovsky3,4

Departments of Animal Science,3 Obstetrics and Gynecology,4 Veterinary Pathobiology,5 University of Missouri– Columbia, Missouri 65211

Animal spermatids and primary oocytes initially have typical centrosomes comprising pairs of centrioles and pericentriolar fibrous centrosomal proteins. These somatic cell–like centrosomes are partially or completely degenerated during gametogenesis. Centrosome reduction during spermiogenesis comprises attenuation of microtubule nucleation function, loss of pericentriolar material, and centriole degeneration. Centrosome reduction during oogenesis is due to complete degeneration of centrioles, which leads to dispersal of the pericentriolar centrosomal proteins, loss of replicating capacity of the spindle poles, and switching to acentrosomal mode of spindle organization. Oocyte centrosome reduction plays an important role in preventing parthenogenetic embryogenesis and balancing centrosome number in the embryonic cells.

1 Supported by funding from the USDA (award 2002-02069) and Food for the 21st Century Program, University of Missouri—Columbia, to P.S.

2 Correspondence: G. Manandhar, University of Missouri, S-141 ASRC, 920 East Campus Drive, Columbia, MO 65211. FAX: 573 884 5540; manandharg{at}missouri.edu




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