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BOR - Papers in Press, published online ahead of print October 13, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.035030
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biolreprod.104.035030v1
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BIOLOGY OF REPRODUCTION 72, 487–491 (2005)
DOI: 10.1095/biolreprod.104.035030
© 2005 by the Society for the Study of Reproduction, Inc.

Recapitulation of the Ovum Mutant (Om) Phenotype and Loss of Om Locus Polarity in Cloned Mouse Embryos1

Shaorong Gao3, Guangming Wu3, Zhiming Han3, Elena de la Casa-Esperón3, Carmen Sapienza3,4, and Keith E. Latham2,3,5

The Fels Institute for Cancer Research and Molecular Biology,3 Department of Pathology,4 Department of Biochemistry,5 Temple University School of Medicine, Philadelphia, Pennsylvania 19140

The ovum mutant (Om) locus in mice affects early interactions between sperm and egg that in turn affect viability of embryos beyond the morula stage. Crosses of DDK females to males of many other inbred strains are 95% lethal around the morula stage, whereas reciprocal crosses are fully viable. Available data indicate that the early lethality is the result of an interaction between a factor in the ooplasm and the paternal genome. In this study, we examined whether this lethal interaction would likewise occur in cloned embryos produced by somatic cell nuclear transfer. We find that the Om effect is recapitulated but that the parental origin effect at the Om locus is no longer evident in cloned embryos.

1 Supported in part by grants from the National Institute of Child Health and Human Development (NIH/NICHD) (HD 38381 to K.E.L. and HD34508 to C.S.) and the National Institute of General Medical Sciences (GM62537 to C.S.).

2 Correspondence: Keith E. Latham, 3307 North Broad St., Philadelphia, PA 19140. FAX: 215 707 1454; klatham{at}temple.edu




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