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BOR - Papers in Press, published online ahead of print November 10, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.035444
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BIOLOGY OF REPRODUCTION 72, 612–618 (2005)
DOI: 10.1095/biolreprod.104.035444
© 2005 by the Society for the Study of Reproduction, Inc.

Maternal Factors Controlling Blastomere Fragmentation in Early Mouse Embryos1

Zhiming Han4, Young Gie Chung3,4, Shaorong Gao4, and Keith E. Latham2,4,5

The Fels Institute for Cancer Research and Molecular Biology4 Department of Biochemistry,5 Temple University School of Medicine, Philadelphia, Pennsylvania 19140

Interactions between sperm and egg are required to maintain embryo viability and cellular integrity. Differential transcriptional activities and epigenetic differences that include genomic imprinting provide mechanisms by which complementary parental genome functions support early embryogenesis. We previously showed that cytofragmentation can be influenced by the specific combination of maternal and paternal genotypes. Using maternal pronuclear transfer in mouse embryos, we examined the cellular basis for the maternal genotype effect. We found that the maternal genotype effect is predominantly controlled by the maternal pronucleus, with a lesser role played by the ooplasm. This effect of the maternal pronucleus is sensitive to {alpha}-amanitin treatment. The effect of the maternal component of the embryonic genome on cytofragmentation constitutes the earliest known effect of the embryonic genome on mammalian embryo phenotype. The results also indicate that clinical procedures seeking to define or manipulate oocyte quality in humans should take into account early effects of the embryonic genome, particularly the maternal genome.

1 Supported by grant HD 41440 from the National Institute of Child Health and Human Development.

2 Correspondence: Keith Latham, The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N. Broad Street, Philadelphia, PA 19140. FAX: 215 707 1454; klatham{at}temple.edu

3 Current address: Advanced Cell Technology, One Innovation Drive, Biotech Three, Worcester, MA 01605




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L.-B. Wan, H. Pan, S. Hannenhalli, Y. Cheng, J. Ma, A. Fedoriw, V. Lobanenkov, K. E. Latham, R. M. Schultz, and M. S. Bartolomei
Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development
Development, August 15, 2008; 135(16): 2729 - 2738.
[Abstract] [Full Text] [PDF]


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Copyright © 2005 by the Society for the Study of Reproduction.