Biol Reprod
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print December 15, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.037234
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
72/4/1004    most recent
biolreprod.104.037234v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Redmer, D. A.
Right arrow Articles by Wallace, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Redmer, D. A.
Right arrow Articles by Wallace, J. M.
Agricola
Right arrow Articles by Redmer, D. A.
Right arrow Articles by Wallace, J. M.
BIOLOGY OF REPRODUCTION 72, 1004–1009 (2005)
DOI: 10.1095/biolreprod.104.037234
© 2005 by the Society for the Study of Reproduction, Inc.

Influence of Maternal Nutrition on Messenger RNA Expression of Placental Angiogenic Factors and Their Receptors at Midgestation in Adolescent Sheep1

Dale A. Redmer2,3,4,, Raymond P. Aitken3, John S. Milne3, Lawrence P. Reynolds4, and Jacqueline M. Wallace3

Rowett Research Institute,3 Bucksburn, Aberdeen AB21 9SB, United Kingdom Department of Animal and Range Sciences,4 North Dakota State University, Fargo, North Dakota 58105

Previous studies have shown that placental growth and pregnancy outcome are severely compromised in adolescent ewes overnourished to promote rapid maternal growth. Using this paradigm, the aim of the present study was to investigate expression of the major angiogenic factors and their receptors in the placenta at the onset of the most rapid phase of fetal growth. Singleton pregnancies to a single sire were established by embryo transfer, and thereafter, adolescent dams were offered a high or moderate nutrient intake predicted to induce compromised or normal fetoplacental size at term, respectively. Ovine-specific oligonucleotide probe and primer sets for several angiogenic factors and their receptors were developed for quantitative real-time reverse transcription-polymerase chain reaction determination of placentome mRNA expression at Day 81 of gestation. Total placentome weight and fetal weight were equivalent in high- compared with moderate-intake groups at this stage of gestation. Placentome expression of the angiogenic factors, vascular endothelial growth factor, angiopoietins 1 and 2, and nitric oxide synthase 3, were reduced in overfed ewes. Similarly, level of expression of vascular endothelial growth factor/vascular permeability factor receptor (FLT1) was less in overfed ewes. Thus, in the adolescent, maternal overnutrition has a negative impact on midgestation placental angiogenic factor/ receptor expression. This may impact placental vascularity and explain why uteroplacental mass, blood flow, and nutrient uptake are compromised in late pregnancy, resulting in low-birth-weight offspring.

1 Supported by the Scottish Executive Environment and Rural Affairs Department as part of the core funding to the Rowett Research Institute (J.M.W.) and supported in part by NIH grant HL64141 and Hatch Project ND01705 (D.A.R. and L.P.R.).

2 Correspondence: Dale A. Redmer, Dept. of Animal and Range Sciences, 187 Hultz Hall, North Dakota State University, Fargo, ND 58105-5727. FAX: 701 231 7590; dale.redmer{at}ndsu.edu




This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Wallace, J. S. Milne, R. P. Aitken, and W. W. Hay Jr.
Sensitivity to metabolic signals in late-gestation growth-restricted fetuses from rapidly growing adolescent sheep
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1233 - E1241.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Khorram, N. Khorram, M. Momeni, G. Han, J. Halem, M. Desai, and M. G. Ross
Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R745 - R753.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Luther, R. Aitken, J. Milne, M. Matsuzaki, L. Reynolds, D. Redmer, and J. Wallace
Maternal and Fetal Growth, Body Composition, Endocrinology, and Metabolic Status in Undernourished Adolescent Sheep
Biol Reprod, August 1, 2007; 77(2): 343 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Luther, J. Milne, R. Aitken, M. Matsuzaki, L. Reynolds, D. Redmer, and J. Wallace
Placental Growth, Angiogenic Gene Expression, and Vascular Development in Undernourished Adolescent Sheep
Biol Reprod, August 1, 2007; 77(2): 351 - 357.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
R. G Lea, P. Wooding, I. Stewart, L. T Hannah, S. Morton, K. Wallace, R. P Aitken, J. S Milne, T. R Regnault, R. V Anthony, et al.
The expression of ovine placental lactogen, StAR and progesterone-associated steroidogenic enzymes in placentae of overnourished growing adolescent ewes
Reproduction, April 1, 2007; 133(4): 785 - 796.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. P. Borowicz, D. R. Arnold, M. L. Johnson, A. T. Grazul-Bilska, D. A. Redmer, and L. P. Reynolds
Placental Growth Throughout the Last Two Thirds of Pregnancy in Sheep: Vascular Development and Angiogenic Factor Expression
Biol Reprod, February 1, 2007; 76(2): 259 - 267.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
A. T Grazul-Bilska, C. Navanukraw, M. L. Johnson, D. A Arnold, L. P Reynolds, and D. A Redmer
Expression of endothelial nitric oxide synthase in the ovine ovary throughout the estrous cycle.
Reproduction, October 1, 2006; 132(4): 579 - 587.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
G. Wu, F. W. Bazer, J. M. Wallace, and T. E. Spencer
BOARD-INVITED REVIEW: Intrauterine growth retardation: Implications for the animal sciences
J Anim Sci, September 1, 2006; 84(9): 2316 - 2337.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
K. A Vonnahme, D. A Redmer, E. Borowczyk, J. J Bilski, J. S Luther, M. L. Johnson, L. P Reynolds, and A. T Grazul-Bilska
Vascular composition, apoptosis, and expression of angiogenic factors in the corpus luteum during prostaglandin F2{alpha}-induced regression in sheep.
Reproduction, June 1, 2006; 131(6): 1115 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. P. Reynolds, J. S. Caton, D. A. Redmer, A. T. Grazul-Bilska, K. A. Vonnahme, P. P. Borowicz, J. S. Luther, J. M. Wallace, G. Wu, and T. E. Spencer
Evidence for altered placental blood flow and vascularity in compromised pregnancies
J. Physiol., April 1, 2006; 572(1): 51 - 58.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. P. Reynolds, P. P. Borowicz, K. A. Vonnahme, M. L. Johnson, A. T. Grazul-Bilska, D. A. Redmer, and J. S. Caton
Placental angiogenesis in sheep models of compromised pregnancy
J. Physiol., May 15, 2005; 565(1): 43 - 58.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. M. Wallace, T. R. H. Regnault, S. W. Limesand, W. W. Hay Jr, and R. V. Anthony
Investigating the causes of low birth weight in contrasting ovine paradigms
J. Physiol., May 15, 2005; 565(1): 19 - 26.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Society for the Study of Reproduction.