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BOR - Papers in Press, published online ahead of print December 29, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.036541
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BIOLOGY OF REPRODUCTION 72, 1101–1108 (2005)
DOI: 10.1095/biolreprod.104.036541
© 2005 by the Society for the Study of Reproduction, Inc.

Fra1 Activity in the Frog, Rana esculenta, Testis: A New Potential Role in Sperm Transport1

Gilda Cobellis , Monica Lombardi , Donatella Scarpa , Gaia Izzo , Giulia Fienga , Rosaria Meccariello , Riccardo Pierantoni 2 , and Silvia Fasano 

Dipartimento di Medicina Sperimentale, Sezione F. Bottazzi, II Università di Napoli, 80138 Naples, Italy

Using an anti-Fos family member antibody, we have previously described in Rana esculenta testis the presence of a nuclear, 43 kDa protein that we hypothesized to be Fra1. With the assistance of an antibody against Fra1 that does not cross-react with other Fos family members, here we report data on Fra1 expression, localization, and putative activity in Rana esculenta testis during its annual reproductive cycle. Western blot analysis confirms that the nuclear, 43 kDa protein is Fra1. Immunocytochemistry validates the Western blot results and shows cytoplasmic and nuclear immunostaining of Fra1 in peritubular myoid cells, efferent ducts, and blood vessels. We report for the first time in a vertebrate, experimental evidence showing that the expression of Fra1 is related to peritubular myoid cells during sperm transport from the tubular compartment to efferent ducts.

AP-1, blood vessel, efferent duct, Fos family proteins, Fra1, male reproductive tract, male sexual function, peritubular myoid cell, proto-oncogenes, reproduction, spermiation, sperm motility and transport, testis

1 Supported by the fellowships MURST "COFIN" (40%); and Regione Campania, Agenzia Spaziale Italiana (ASI) and Provincia di Salerno (60%).

2 Correspondence. FAX 39 081 5667500; riccardo.pierantoni{at}unina2.it




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G. Cobellis, G. Cacciola, D. Scarpa, R. Meccariello, R. Chianese, M. F. Franzoni, K. Mackie, R. Pierantoni, and S. Fasano
Endocannabinoid System in Frog and Rodent Testis: Type-1 Cannabinoid Receptor and Fatty Acid Amide Hydrolase Activity in Male Germ Cells
Biol Reprod, July 1, 2006; 75(1): 82 - 89.
[Abstract] [Full Text] [PDF]


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