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BOR - Papers in Press, published online ahead of print May 25, 2005.
Biol Reprod 2005, 10.1095/biolreprod.105.040436
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BIOLOGY OF REPRODUCTION 73, 619–626 (2005)
DOI: 10.1095/biolreprod.105.040436
© 2005 by the Society for the Study of Reproduction, Inc.

Adrenomedullin Enhances Invasion by Trophoblast Cell Lines1

Xiaoquan Zhang , Kortney E. Green , Chandra Yallampalli , and Yuan Lin Dong 2 

Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555

We have tested the hypothesis that adrenomedullin (ADM), a multifunctional peptide hormone, works as a trophoblast proinvasion factor. Our results showed that ADM receptor components—the mRNA and proteins of calcitonin receptor-like receptor (CALCRL) and receptor activity modifying proteins (RAMPs)—were expressed by human choriocarcinoma JAr cells and first-trimester cytotrophoblast HTR-8/SV neo cells. ADM stimulates both JAr and HTR-8/SV neo cell proliferation. The invasion capabilities of JAr cells and HTR-8/SV neo cells were also enhanced by ADM, and this was associated with increased gelatinolytic activity and reduced plasminogen activator inhibitor-1 mRNA expression (SERPINE1). Our data support the notion that ADM may be involved in the human implantation process via regulating trophoblast proliferation and differentiation.

adrenomedullin, cell proliferation, growth factors, implantation, placenta, pregnancy, trophoblast, trophoblast invasion

1 Supported by grant HL70883 from the National Institutes of Health to Y.-L.D.

2 Correspondence: Yuan-Lin Dong, Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd., MRB, 11.138, Route 1062, Galveston, TX 77555-1062. FAX: 409 747 0475;ydong{at}utmb.edu






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Copyright © 2005 by the Society for the Study of Reproduction.