Biol Reprod
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print August 3, 2005.
Biol Reprod 2005, 10.1095/biolreprod.105.043091
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
73/6/1102    most recent
biolreprod.105.043091v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pierre, A.
Right arrow Articles by Monget, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pierre, A.
Right arrow Articles by Monget, P.
Agricola
Right arrow Articles by Pierre, A.
Right arrow Articles by Monget, P.
BIOLOGY OF REPRODUCTION 73, 1102–1108 (2005)
DOI: 10.1095/biolreprod.105.043091
© 2005 by the Society for the Study of Reproduction, Inc.

Research Article

Bone Morphogenetic Protein 5 Expression in the Rat Ovary: Biological Effects on Granulosa Cell Proliferation and Steroidogenesis1

Alice Pierre , Claudine Pisselet 3 , Joelle Dupont , Martine Bontoux , and Philippe Monget 2 

Physiologie de la Reproduction et des Comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France

ABSTRACT

Recently, the role of several elements of the bone morphogenetic protein (BMP) family has been studied in the ovary, some of them being crucial for ovarian function. In the present work, we have studied bone morphogenetic protein 5 (BMP5) expression and its biological role in the rat ovary. BMP5 is expressed by rat granulosa cells (GCs) and exerts specific biological effects on proliferation and steroidogenesis of these cells in an autocrine manner. These effects were shown to be associated with an increase in cyclin D2 protein level and a decrease in steroidogenic acute regulatory (StAR) protein expression in GCs in vitro. Ultimately, BMP5 actions were inhibited by follistatin. Overall, these data show that BMP5 is a novel element of the BMP family that might play a fully paracrine role in rodent ovarian folliculogenesis.

BMP5, follicle-stimulating hormone, granulosa cells, ovary, progesterone, rat

FOOTNOTES

1 Supported by Institut National de la Recherche Agronomique. A.P. was supported by a fellowship from Institut National de la Recherche Agronomique and Région Centre.

2 Correspondence: Philippe Monget, Physiologie de la Reproduction et des Comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France. FAX: 33 2 47 42 77 43; monget{at}tours.inra.fr

3 Deceased.




This article has been cited by other articles:


Home page
 J EndocrinolHome page
S Elis, J Dupont, I Couty, L Persani, M Govoroun, E Blesbois, F Batellier, and P Monget
Expression and biological effects of bone morphogenetic protein-15 in the hen ovary
J. Endocrinol., September 1, 2007; 194(3): 485 - 497.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
P. G Knight and C. Glister
TGF-{beta} superfamily members and ovarian follicle development.
Reproduction, August 1, 2006; 132(2): 191 - 206.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Society for the Study of Reproduction.