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BOR - Papers in Press, published online ahead of print January 18, 2006.
Biol Reprod 2006, 10.1095/biolreprod.105.045997
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BIOLOGY OF REPRODUCTION 74, 772–776 (2006)
DOI: 10.1095/biolreprod.105.045997
© 2006 by the Society for the Study of Reproduction, Inc.

Minireview

New Insights into the Biology of Preeclampsia

Holger Stepan 1 2, Renaldo Faber 2, Nadja Dornhöfer 2, Berthold Huppertz 3, Andrea Robitzki 4, and Thomas Walther 56 

Department of Obstetrics and Gynecology,2 University of Leipzig, 04103 Leipzig, Germany Department of Cell Biology,3 Histology and Embryology, Medical University of Graz, 8010 Graz, Austria Department of Molecular Biological-Biochemical Processing Technology,4 Center of Biotechnology and Biomedicine, University of Leipzig, 04103 Leipzig, Germany Department of Pharmacology,5 Erasmus Medical Center, 3000 Rotterdam, The Netherlands Department of Cardiology,6 Charité, Campus Benjamin Franklin, 12200 Berlin, Germany

Despite recent research progress, the biology of preeclampsia is still poorly understood and neither effective prediction nor causal therapy have yet emerged. Nevertheless, recent studies have documented new and exciting pathophysiological mechanisms for the origin and development of preeclampsia. These studies provide a more differentiated view on alterations of particular peptide systems with strong impact on angiogenesis and cardiovascular regulation in this pregnancy disorder. With the identification of the antiangiogenic factor soluble fms-like tyrosine kinase 1 and the agonistic autoantibody to the angiotensin II type 1 receptor, two factors have been described with a clear linkage to the development of the disease. This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia.

placenta, pregnancy, signal transduction, trophoblast

1 Correspondence: Holger Stepan, Department of Obstetrics and Gynecology, Philipp-Rosenthalstr. 55, 04103 Leipzig, Germany. FAX: 49 341 9723599; holger.stepan{at}medizin.uni-leipzig.de




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