Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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BOR - Papers in Press, published online ahead of print January 18, 2006.
Biol Reprod 2006, 10.1095/biolreprod.105.047829
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BIOLOGY OF REPRODUCTION 74, 816–823 (2006)
DOI: 10.1095/biolreprod.105.047829
© 2006 by the Society for the Study of Reproduction, Inc.

Research Article

Spatio-Developmental Distribution of the Prion-Like Protein Doppel in Mammalian Testis: A Comparative Analysis Focusing on Its Presence in the Acrosome of Spermatids1

C. Serres 2 3, K. Peoc'h 45 , A.M. Courtot 6, C. Lesaffre 3, P. Jouannet 3, and J.L. Laplanche 45 

Université Paris Descartes,3 Faculté de Médecine, 75014 Paris, France Service de Biochimie et Biologie Moléculaire,4 Hôpital Lariboisière, 75010 Paris, France Université Paris Descartes,5 Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France INSERM U566,6 CEA, 92260 Fontenay-aux-Roses, France

ABSTRACT

The first prion-like protein doppel, officially designed as prion protein dublet, does not seem to be needed for prion disease progression, whereas its physiological function seems to be related to male fertility. Its expression is primarily detected in the male genital tract, and Prnd-inactivated male mice are sterile. We investigated the location of Doppel in the testis of various species of mammal to determine its physiological function. Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells in mice, rats, boars, and humans. Doppel is permanently expressed in the Sertoli cells but at different levels according to species. Its expression in testicular germ cells was primarily detected in spermatids, with a transient presence in the acrosome. These data suggest that Doppel may play a physiological role in acrosome biogenesis and may be of use in studies of patients suffering from idiopathic infertility.

acrosome reaction, fertilization, Sertoli cells, spermatid, testis

FOOTNOTES

1 Supported by funds from Université Paris 5 (Bonus Qualité Recherche) and grant EA1752 from the Direction de la Recherche et des Etudes Doctorales.

2 Correspondence: Catherine Serres, Laboratoire de Biologie de la Reproduction, Faculté de Médecine, site de Cochin, 24 rue du Faubourg Saint-Jacques, 75014 Paris, France. FAX: 33 1 44 41 23 02; catherine.serres{at}univ-paris5.fr






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Copyright © 2006 by the Society for the Study of Reproduction.