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BOR - Papers in Press, published online ahead of print January 25, 2006.
Biol Reprod 2006, 10.1095/biolreprod.105.046896
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BIOLOGY OF REPRODUCTION 74, 954–958 (2006)
DOI: 10.1095/biolreprod.105.046896
© 2006 by the Society for the Study of Reproduction, Inc.

Research Article

Mechanism of Action of L-arginine on the Vitality of Spermatozoa is Primarily Through Increased Biosynthesis of Nitric Oxide

Sudha Srivastava 1 3, Prashant Desai 2 4, Evans Coutinho 4, and Girjesh Govil 3

Tata Institute of Fundamental Research,3 Colaba, Mumbai-5, India Department of Pharmaceutical Chemistry,4 Bombay College of Pharmacy, Kalina, Mumbai-98, India

ABSTRACT

The ability of sperm to fertilize the egg is primarily dependent on sperm motility and membrane integrity. Nitric oxide (NO) plays a decisive role in regulating multiple functions within the male reproductive system. The aim of the present study is to determine the mechanism by which L-arginine confers a protective action on spermatozoa obtained from the goat epididymis. NO is synthesized from L-arginine by the enzyme nitric oxide-synthase (NOS) present in spermatozoa. A possible participation of NO and NOS in arginine action has been suggested.

Nitric oxide, sperm, sperm capacitation, sperm maturation, sperm motility and transport

FOOTNOTES

1 Correspondence: Sudha Srivastava, National Facility for High Field NMR, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai-5, India. FAX: + 91 22 22804682; sudha{at}tifr.res.in

2 Current address: Department of Medical Chemistry, University of Mississippi, University, MS 38677.






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Copyright © 2006 by the Society for the Study of Reproduction.