HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) [Supplemental Movies] All Versions of this Article: 77/1/37    most recent biolreprod.107.060186v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal My Folders Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jin, J. Articles by Yan, W. Search for Related Content PubMed PubMed Citation Articles by Jin, J. Articles by Yan, W. Agricola Articles by Jin, J. Articles by Yan, W.

Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility in the Mouse¹

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557

ABSTRACT

Catsper3 and Catsper4 are two recently identified testis-specific genes homologous to Catsper1 and Catsper2 that have been shown to play an essential role in sperm hyperactivated motility and male fertility in mice. Here we report that Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions. Our data demonstrate that both CATSPER3 and CATSPER4 are required for hyperactivated sperm motility during capacitation and for male fertility. The present study also demands a revisit to the idiopathic male infertility patients who show normal sperm counts and normal initial motility for defects in sperm hyperactivated motility and for potential CATSPER gene mutations. The CATSPER channel also may be an excellent drug target for male contraceptives.

fertilization, infertility, ion channel, sperm, spermatogenesis, sperm capacitation, sperm maturation, sperm motility and transport, testis

³These authors contributed equally to this work.

¹Supported by a start-up fund from the University of Nevada, Reno, and also in part by National Institutes of Health grant HD050281 to W.Y.

³These authors contributed equally to this work.

Correspondence: ²Wei Yan, Department of Physiology and Cell Biology, University of Nevada School of Medicine, 1664 North Virginia St., MS 352, Reno, NV 89557. FAX: 775 784 6903; e-mail: wyan{at}unr.edu

This article has been cited by other articles:

				J. Xia and D. Ren Egg Coat Proteins Activate Calcium Entry into Mouse Sperm via CATSPER Channels Biol Reprod, June 1, 2009; 80(6): 1092 - 1098. [Abstract] [Full Text] [PDF]

				G. M. Gibbs, K. Roelants, and M. K. O'Bryan The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins--Roles in Reproduction, Cancer, and Immune Defense Endocr. Rev., December 1, 2008; 29(7): 865 - 897. [Abstract] [Full Text] [PDF]

				S. S. Suarez Control of hyperactivation in sperm Hum. Reprod. Update, November 1, 2008; 14(6): 647 - 657. [Abstract] [Full Text] [PDF]

				K. A. Sutton, M. K. Jungnickel, and H. M. Florman A polycystin-1 controls postcopulatory reproductive selection in mice PNAS, June 24, 2008; 105(25): 8661 - 8666. [Abstract] [Full Text] [PDF]

				V. Torres-Flores, N. L. Garcia-Sanchez, and M. T. Gonzalez-Martinez Intracellular Sodium Increase Induced by External Calcium Removal in Human Sperm J Androl, January 1, 2008; 29(1): 63 - 69. [Abstract] [Full Text] [PDF]

				S. Ro, C. Park, R. Song, D. Nguyen, J. Jin, K. M. Sanders, J. R. McCarrey, and W. Yan Cloning and expression profiling of testis-expressed piRNA-like RNAs RNA, October 1, 2007; 13(10): 1693 - 1702. [Abstract] [Full Text] [PDF]