Biol Reprod Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print April 30, 2008.
Biol Reprod 2008, 10.1095/biolreprod.108.068783
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
79/2/328    most recent
biolreprod.108.068783v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ye, X.
Right arrow Articles by Chun, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ye, X.
Right arrow Articles by Chun, J.
Agricola
Right arrow Articles by Ye, X.
Right arrow Articles by Chun, J.
BIOLOGY OF REPRODUCTION 79, 328–336 (2008)
DOI: 10.1095/biolreprod.108.068783
© 2008 by the Society for the Study of Reproduction, Inc.

Testis; 

Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling1

Xiaoqin Ye 3 4, Michael K. Skinner 5, Grace Kennedy 4, and Jerold Chun 2 4

Department of Molecular Biology,4 The Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037 Center for Reproductive Biology,5 School of Molecular Bioscience, Washington State University, Pullman, Washington 99164-4231

ABSTRACT

Approximately half of all infertility cases can be attributed to male reproductive dysfunction for which low sperm count is a major contributing factor. The current study identified receptor-mediated lysophosphatidic acid (LPA) signaling as a new molecular component influencing male fertility. LPA is a small signaling phospholipid, the effects of which are mediated through at least five G protein-coupled receptors, named LPA 1–5. LPA1/2/3, but not LPA4/5, show high expression in mouse testis. Mice deficient in LPA1/2/3 showed a testosterone-independent reduction of mating activity and sperm production, with an increased prevalence of azoospermia in aging animals. A significant increase of germ cell apoptosis also was observed in testes. Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis.

germ cell apoptosis and proliferation, LPA and S1P, sperm count, spermatogenesis, testis

FOOTNOTES

1Supported by National Institutes of Health grant R01 HD050685 to J.C.

Correspondence: 2Correspondence: Jerold Chun, Department of Molecular Biology, ICND 118, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037. FAX: 858 784 7084; e-mail: jchun{at}scripps.edu

3Current address: Department of Physiology and Pharmacology, College of Veterinary Medicine, and Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602.




This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
A. Skoura and T. Hla
Lysophospholipid receptors in vertebrate development, physiology, and pathology
J. Lipid Res., April 1, 2009; 50(Supplement): S293 - S298.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the Society for the Study of Reproduction.