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BOR - Papers in Press, published online ahead of print June 18, 2008.
Biol Reprod 2008, 10.1095/biolreprod.107.067348
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BIOLOGY OF REPRODUCTION 79, 468–474 (2008)
DOI: 10.1095/biolreprod.107.067348
© 2008 by the Society for the Study of Reproduction, Inc.

research-article

The Rhox Homeobox Gene Family Shows Sexually Dimorphic and Dynamic Expression During Mouse Embryonic Gonad Development1

Hinda Daggag 3, Terje Svingen 4, Patrick S. Western 3, Jocelyn A. van den Bergen 3, Peter J. McClive 3, Vincent R. Harley 5, Peter Koopman 4, and Andrew H. Sinclair 2 3

Murdoch Children's Research Institute and Department of Pediatrics,3 University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia Institute for Molecular Bioscience,4 The University of Queensland, Brisbane, Queensland 4072, Australia Prince Henry's Institute for Medical Research,5 Monash Medical Centre, Clayton, Victoria 3168, Australia

ABSTRACT

Reproductive capacity is fundamental to the survival of all species. Consequently, much research has been undertaken to better understand gametogenesis and the interplay between germ cells and the somatic cell lineages of the gonads. In this study, we have analyzed the embryonic expression pattern of the X-linked gene family Reproductive homeobox genes on the X chromosome (Rhox) in mice. Our data show that eight members of the Rhox gene family are developmentally regulated in sexually dimorphic and temporally dynamic patterns in the developing germ cells during early gonadogenesis. These changes coincide with critical stages of differentiation where the germ cells enter either mitotic arrest in the testis or meiotic arrest in the ovary. Finally, we show that Rhox8 (Tox) is the only member of the Rhox gene family that is expressed in the somatic compartment of the embryonic gonads. Our results indicate that the regulation of Rhox gene expression and its potential function during embryogenesis are quite distinct from those previously reported for Rhox gene regulation in postnatal gonads.

gene regulation, germ cells, gonad development, homeobox, reproduction, Rhox genes

FOOTNOTES

1 Supported by a National Health & Medical Research Program grant to A.H.S., P.K., and V.R.H. and by an Australian Research Council Centre of Excellence grant to A.H.S. and P.K.

Correspondence: 2FAX: 61 3 8341 6429; e-mail: andrew.sinclair{at}mcri.edu.au






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