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BOR - Papers in Press, published online ahead of print August 13, 2008.
Biol Reprod 2008, 10.1095/biolreprod.108.067595
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BIOLOGY OF REPRODUCTION 79, 1148–1152 (2008)
DOI: 10.1095/biolreprod.108.067595
© 2008 by the Society for the Study of Reproduction, Inc.

Effects of Androgens on Serum Concentrations of Gonadotropins and Ovarian Steroids in Gilts1

Esbal Jiménez , Horacio Cárdenas , and William F. Pope 2

Department of Animal Sciences, The Ohio State University, Columbus, Ohio 43210

ABSTRACT

To examine how androgens affect endocrine events associated with increased ovulation rate, gilts were injected with androgen receptor agonists, an antagonist, or a combination of both. Blood samples were collected hourly from Day 13 to estrus (Day 0 = onset of estrus) coincident with gilts (n = 6 per treatment) receiving daily treatments of vehicle (corn oil), 10 mg of testosterone, 10 mg of 5 alpha-dihydrotestosterone (dihydrotestosterone), 1.5 g of flutamide (an androgen receptor antagonist), testosterone plus flutamide, or dihydrotestosterone plus flutamide. Treatment of gilts with testosterone or dihydrotestosterone alone increased (P < 0.05) concentrations of FSH in serum, and these effects were blocked by cotreatment with flutamide. Estradiol-17beta and androstenedione concentrations in serum were increased (P < 0.05) at 2 h after injection of testosterone or testosterone plus flutamide but not after dihydrotestosterone treatment, probably because of the role of testosterone as a substrate for estradiol-17beta and androstenedione synthesis. There were no effects of the six treatments on serum concentrations of progesterone during luteolysis, but treating gilts with testosterone shortened (P < 0.05) the proestrous period. Total embryonic loss by Day 11 in gilts treated with dihydrotestosterone was reversed when gilts were cotreated with dihydrotestosterone plus flutamide. Results of this experiment indicated that androgen actions both increased FSH secretion and reduced embryonic survival by a mechanism(s) dependent on the androgen receptor.

androgen receptor, androgens, follicle-stimulating hormone, gonadotropins, ovarian steroids, pig

FOOTNOTES

1Supported by National Research Initiative Competitive grant 2003-35203-13489 from the USDA Cooperative State Research, Education and Extension Service. Salaries and research support were also provided by state and federal funds appropriated to the Ohio Agricultural Research and Development Center and The Ohio State University. Manuscript no. 4/08AS.

Correspondence: 2William F. Pope, Department of Animal Sciences, The Ohio State University, OARDC, 2027 Coffey Rd., Columbus, OH 43210. FAX: 614 292 7116; e-mail: pope.2{at}osu.edu






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Copyright © 2008 by the Society for the Study of Reproduction.