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Biology of Reproduction, Vol 8, 43-47, Copyright © 1973 by Society for the Study of Reproduction

Comparative mparative Effects of Antiserum to Luteinizing Hormone on Pseudopregnancy and Pregnancy Induced in the Same Rat

RHODA MANECKJEE 1, H. G. MADHWA RAJ 1, , and N. R. MOUDGAL 1

1 Endocrinology Laboratory, Department of Biochemistry, Indian Institute of Science, Bangalore-12, India


The comparative role of luteinizing hormone (LH) in maintaining pregnancy and histamine-induced decidualization in the rat was studied with the help of a new system, wherein the above two states could be brought about simultaneously in the same animal, but in different uterine horns. Specific and well-characterized LH antiserum, administered daily, both during the pre-trauma (days 1-4) and post-trauma (days 5-8) periods, resulted in the termination of pregnancy and inhibition of decidualization. This antiserum effect could be reversed by suitable steroid therapy. Results suggest that the antiserum blockade of ovarian steroidogenesis continued even after cessation of its treatment.

Early pregnancy and decidualization seem directly comparable in that both are dependent upon LH to stimulate the ovarian synthesis of much-needed progesterone and estrogen.

 Submitted on August 9, 1971
Revised on May 30, 1972
Accepted on September 29, 1972






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Copyright © 1973 by the Society for the Study of Reproduction.