Biol Reprod Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LINKIE, D. M.
Right arrow Articles by NISWENDER, G. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LINKIE, D. M.
Right arrow Articles by NISWENDER, G. D.
Agricola
Right arrow Articles by LINKIE, D. M.
Right arrow Articles by NISWENDER, G. D.

Biology of Reproduction, Vol 8, 48-57, Copyright © 1973 by Society for the Study of Reproduction

Characterization of Rat Placental Luteotropin

Physiological and Physicochemical Properties

DANIEL M. LINKIE 1, and GORDON D. NISWENDER 1

1 Reproductive Endocrinology Program, The Departments of Zoology and Pathology, The University of Michigan, Ann Arbor, Michigan 48104


Extracts of placentae and sera from rats 11, 12, and 13 days pregnant supported the decidual reaction in mature, hypophysectomized, pseudopregnant rats, with maximal potency noted on Day 12. Extracts of tissues or sera obtained on Days 10, 14, and 16 of pregnancy did not sustain deciduomata. Serum progesterone levels in decidualized rats were elevated as opposed to rats not supporting the decidual reaction. The luteotropic activity of rat placentae was also demonstrated following administration of placental tissue to the hypophysectomized pregnant rat. Placental luteotropic activity was dose-related, and the active factor could be lyophilized repeatedly without loss of activity. The biologically active placental component(s) was characterized as a heat-labile protein of approximately 25,000-50,000 molecular weight. These data affirm the critical endocrine role of the rat placenta in supplanting the pituitary and maintaining corpus luteum functions.

Submitted on December 13, 1971
Revised on October 2, 1972
Accepted on October 2, 1972




This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
Y.-J. Chen, Q. Feng, and Y.-X. Liu
Expression of the Steroidogenic Acute Regulatory Protein and Luteinizing Hormone Receptor and Their Regulation by Tumor Necrosis Factor {alpha} in Rat Corpora Lutea
Biol Reprod, February 1, 1999; 60(2): 419 - 427.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 by the Society for the Study of Reproduction.