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BIOLOGY OF REPRODUCTION 72, 257–257 (2005)
DOI: 10.1095/biolreprod.104.039297
© 2005 by the Society for the Study of Reproduction, Inc.

Highlights

Recapitulation of the Ovum Mutant (Om) Phenotype and Loss of Om Locus Polarity in Cloned Mouse Embryos. Shaorong Gao, Guangming Wu, Zhiming Han, Elena de la Casa-Esperón, Carmen Sapienza, and Keith E. Latham. Biol Reprod 2005; 72:487–491. published 13 October 2004; 10.1095/biolreprod.104.035030

Fertilization results in the introduction of a paternal genome into the egg cytoplasm. Factors in the egg cytoplasm must interact appropriately with the paternal genome to sustain embryonic development. It has been known for many years that fertilization of strain DDK eggs with sperm from any other strain results in embryonic lethality at about the morula stage. Thus, there is an incompatibility of the DDK egg cytoplasm with the paternal genomes of other "alien" strains. On page 487, a paper by Gao et al. has addressed the question whether effects of the DDK egg cytoplasm still recognize an "alien" genome in somatic cells using somatic cell nuclear transfer. It is reported that, after engaging in complex genetic gymnastics, the alien genome in the somatic cell nuclei is still recognized by DDK egg cytoplasm causing embryonic death. The authors stress that these results demonstrate the importance of considering the interactions of egg cytoplasmic factors with alien genomes introduced in cloning experiments.

John Eppig, and Mary Ann Handel





This Article
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