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DOI 10.1095/biolreprod.106.052019
Highlights. Biol Reprod 2006; 74: 449. DOI 10.1095/biolreprod.106.050856
The editorial comment included with the March 2006 Highlights inadvertently created some confusion. The comment did not apply to the paper under which it appeared; the editors apologize for the unintended association between the highlighted paper and the editorial comment. The March Highlights is reprinted below with the editorial comment more appropriately attributed only to the Editors-in-Chief.
Expression of a Dominant Negative Fibroblast Growth Factor Receptor in Developing Gonadotropin-Releasing Hormone Neurons Disrupts Axon Outgrowth and Targeting to the Median Eminence.
John C. Gill and Pei-San Tsai. Biol Reprod 2006; 74:463–472. Published online ahead of print 9 November 2005; 10.1095/biolreprod.105.046904
Axon targeting. During development, GnRH neurons must first migrate into the forebrain then extend axonal processes to the median eminence before reproductive neuroendocrine function can commence. Gill and Tsai have studied the latter part of this developmental program. Using a transgenic mouse model in which a dominant-negative form of the FGF receptor is genetically targeted to GnRH neurons, they demonstrate reduced GnRH neuron targeting in vivo. To understand the mechanisms for this, they generated cultures of embryonic GnRH neurons at the time of axon targeting. In cultures from transgenic mice, basal neurite outgrowth, neurite outgrowth in response to FGF, and signaling via FGF receptors were all compromised. Further, GnRH neurons expressing the dominant-negative FGF receptor exhibited a reduced ability to target towards a median eminence co-culture. Together these data provide compelling evidence for a role of FGFs in the targeting of GnRH axons in vivo and further suggest this effect is at least in part directly on the GnRH neuron itself. — , , , and
Seeing double.
The Highlights usually focus on exciting new advances in the field of reproductive biology. However, the recent turmoil in our field over duplicated and manipulated images deserves comment. Dual publication of data, of course, flies in the face of internationally accepted standards for scientific publication (see Ethical Guidelines for Publication in Biology of Reproduction). BOR is not immune to such problems, any more than is any other journal. Fortunately, the sharp eyes of rigorous reviewers catch most of such cases, but recent events indicate a need for all of us to evaluate our own scientific "housekeeping" practices. Detailed, dated, and fully annotated image files are essential; various proprietary and freeware programs are available to facilitate this. Moreover, inappropriate image manipulation can be an innocent outcome when the unwary deal with professional software. With respect to the latter problem, we refer you to a helpful and eye-opening commentary by Michael Rossner, Managing Editor of Journal of Cell Biology (2004 J Cell Biol 166:11–15). — and
DOI 10.1095/biolreprod.106.052027
Cathy K. Naughton, Sanjay Jain, Amy M. Strickland, Akshay Gupta, and Jeffrey Milbrandt. Glial Cell-Line Derived Neurotrophic Factor-Mediated RET Signaling Regulates Spermatogonial Stem Cell Fate. Biol Reprod 2006; 74: 314–321. DOI 10.1095/biolreprod.105.047365
The above-referenced paper did not correctly note all corresponding authors. The corrected author list, affiliations, and footnotes appear below.
Cathy K. Naughton,6 Sanjay Jain,,7 Amy M. Strickland,6 Akshay Gupta,6 and Jeffrey Milbrandt,8
Divisions of Urology,6 Endocrinology and Oncology,7 Department of Surgery Department of Pathology and Immunology,8 Washington University School of Medicine, St. Louis, Missouri 63110
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