Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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BOR - Papers in Press, published online ahead of print April 30, 2008.
Biol Reprod 2008, 10.1095/biolreprod.108.068783
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BIOLOGY OF REPRODUCTION 79, 328–336 (2008)
DOI: 10.1095/biolreprod.108.068783
© 2008 by the Society for the Study of Reproduction, Inc.

research-article

Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling1

Xiaoqin Ye 3 4, Michael K. Skinner 5, Grace Kennedy 4, and Jerold Chun 2 4

Department of Molecular Biology,4 The Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037 Center for Reproductive Biology,5 School of Molecular Bioscience, Washington State University, Pullman, Washington 99164-4231

ABSTRACT

Approximately half of all infertility cases can be attributed to male reproductive dysfunction for which low sperm count is a major contributing factor. The current study identified receptor-mediated lysophosphatidic acid (LPA) signaling as a new molecular component influencing male fertility. LPA is a small signaling phospholipid, the effects of which are mediated through at least five G protein-coupled receptors, named LPA 1–5. LPA1/2/3, but not LPA4/5, show high expression in mouse testis. Mice deficient in LPA1/2/3 showed a testosterone-independent reduction of mating activity and sperm production, with an increased prevalence of azoospermia in aging animals. A significant increase of germ cell apoptosis also was observed in testes. Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis.

germ cell apoptosis and proliferation, LPA and S1P, sperm count, spermatogenesis, testis

FOOTNOTES

3Current address: Department of Physiology and Pharmacology, College of Veterinary Medicine, and Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602.

1Supported by National Institutes of Health grant R01 HD050685 to J.C.

Correspondence: 2Jerold Chun, Department of Molecular Biology, ICND 118, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037. FAX: 858 784 7084; e-mail: jchun{at}scripps.edu






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Copyright © 2008 by the Society for the Study of Reproduction.