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BOR - Papers in Press, published online ahead of print December 11, 2002.
Biol Reprod 2002, 10.1095/biolreprod.101.000679
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Submitted October 19, 2001
Returned for revision October 31, 2001
Accepted December 2, 2002

Ovary


Vascular Endothelial Growth Factor Stimulates Preantral Follicular Growth in the Rat Ovary

Douglas R. Danforth *, Laura K. Arbogast , Sue Ghosh , Alexandra Dickerman , Rana Rofagha , Chad I. Friedman

* To whom correspondence should be addressed. E-mail: danforth.2{at}osu.edu.

Abstract

The regulation of preantral follicle growth in mammals is poorly understood. The availability of an adequate vascular supply to provide endocrine and paracrine signals may be important in the early states of follicle growth as well as the later states of follicle selection and dominance. The objective of the present study was to investigate whether Vascular Endothelial Growth Factor (VEGF) plays a role in preantral follicle development in the rat ovary. Immature (21 day old) Sprague Dawley rats were injected with 500 ng VEGF in saline or 50 µg diethylstilbestrol (DES) in oil under the bursa of one ovary. The contralateral ovary was injected with a corresponding volume of vehicle. Rats were euthanitized 48h later and the ovaries were removed and analyzed histologically. Intrabursal administration of VEGF significantly increased the number of primary and small secondary, but not large secondary preantral follicles in the ovary, similar to the effect of DES (p<0.05). VEGF stimulated preantral follicle growth in a time- and dose-dependent manner. Subcutaneous DES administration increased the number of primary and secondary follicles, and both subcutaneous and intrabursal estrogen administration stimulated VEGF protein expression in the rat ovary. These data indicate that VEGF stimulates preantral follicle development in the rat ovary, is regulated by estrogen, and may be one of the factors that participate in the regulation of early follicle growth in the rat.



Key words: Ovary • Follicle • Follicular development • Granulosa cells • Growth factors


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