| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The workshop, "Non-Human Primate Models of Menopause," was held on the National Institutes of Health campus in January 2001. The purpose of this workshop, sponsored by the National Institute on Aging, was to review what is known about the female reproductive aging process in various species of monkeys (particularly rhesus, baboons, cynomolgus and chimpanzees), including hormone profiles during the menopausal transition, the occurrence of hot flashes, the extent of age-related and menopause associated changes in hormone levels on metabolism, bone loss, and impaired cardiovascular and cognitive function. While many aspects of the female reproductive aging process appear to be concordant between humans and these monkey species, several important features may be species specific. Those features that appear to parallel the human menopause and aging include general similarity of hormone profiles across the menopausal transition, progression to cycle termination through irregular cycles, declining fertility with age, age-related gains in weight and percent body fat content with tendencies to insulin resistance and glucose intolerance, increased LDL- and decreased HDL-cholesterol, declines in serum DHEA, similarities in temperature regulation systems, protective responses to estrogen replacement following ovariectomy in terms of bone metabolism, lipid profiles and cognitive changes. Important differences include relatively short postmenopausal lifespan, timing in menopause-related changes in hormone secretion, and seasonal menstrual cycles. In addition, the question of whether ovariectomy in young adults is an appropriate model for the consequences of menopause, or even ovariectomy, in middle-aged and older adults is unresolved, and the numbers of older female animals available for research on menopause are very limited. The use of animal models is seen by workshop participants to be crucial for a mechanistic understanding of the human menopausal process and its connections to postmenopausal health problems; however, extensive in-depth and broad-based research is required to determine if non-human primates are appropriate models of the human menopause.
This article has been cited by other articles:
|
|
 |
|
  A. Lacreuse, L. Chennareddi, K. G. Gould, K. Hawkes, S. R. Wijayawardana, J. Chen, K. A. Easley, and J. G. Herndon Menstrual Cycles Continue into Advanced Old Age in the Common Chimpanzee (Pan troglodytes) Biol Reprod, September 1, 2008; 79(3): 407 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Walker and J. G. Herndon Menopause in Nonhuman Primates? Biol Reprod, September 1, 2008; 79(3): 398 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Morrison, R. D. Brinton, P. J. Schmidt, and A. C. Gore Estrogen, Menopause, and the Aging Brain: How Basic Neuroscience Can Inform Hormone Therapy in Women J. Neurosci., October 11, 2006; 26(41): 10332 - 10348. [Full Text] [PDF]
|
|
|
|
|
|
J. L. Downs and H. F. Urbanski Neuroendocrine Changes in the Aging Reproductive Axis of Female Rhesus Macaques (Macaca mulatta) Biol Reprod, October 1, 2006; 75(4): 539 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Uno, H. Fujino, G. Kito, T. Kamataki, and R. Nagata CYP2C76, a Novel Cytochrome P450 in Cynomolgus Monkey, Is a Major CYP2C in Liver, Metabolizing Tolbutamide and Testosterone Mol. Pharmacol., August 1, 2006; 70(2): 477 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Wu, M. B. Zelinski, D. K. Ingram, and M. A. Ottinger Ovarian Aging and Menopause: Current Theories, Hypotheses, and Research Models Experimental Biology and Medicine, December 1, 2005; 230(11): 818 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Malhi, G. P. Adams, and J. Singh Bovine Model for the Study of Reproductive Aging in Women: Follicular, Luteal, and Endocrine Characteristics Biol Reprod, July 1, 2005; 73(1): 45 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Gore, B. M. Windsor-Engnell, and E. Terasawa Menopausal Increases in Pulsatile Gonadotropin-Releasing Hormone Release in a Nonhuman Primate (Macaca mulatta) Endocrinology, October 1, 2004; 145(10): 4653 - 4659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Roth, J. A. Mattison, M. A. Ottinger, M. E. Chachich, M. A. Lane, and D. K. Ingram Aging in Rhesus Monkeys: Relevance to Human Health Interventions Science, September 3, 2004; 305(5689): 1423 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Wood, J. M. Cline, M. S. Anthony, T. C. Register, and J. R. Kaplan Adrenocortical Effects of Oral Estrogens and Soy Isoflavones in Female Monkeys J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2319 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Lane, J. A. Mattison, G. S. Roth, L. J. Brant, and D. K. Ingram Effects of Long-Term Diet Restriction on Aging and Longevity in Primates Remain Uncertain J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2004; 59(5): B405 - B407. [Full Text] [PDF]
|
|
|
|
|
|
M. Leblanc, C. Labrie, A. Belanger, B. Candas, and F. Labrie Bioavailability and Pharmacokinetics of Dehydroepiandrosterone in the Cynomolgus Monkey J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4293 - 4302. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
