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BOR - Papers in Press, published online ahead of print October 30, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.006882
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Submitted June 7, 2002
Returned for revision July 1, 2002
Accepted October 23, 2002

Gamete Biology


Maturation-Promoting Factor Governs Mitogen-Activated Protein Kinase Activation and Interphase Suppression During Meiosis of Rat Oocytes

Liat Ben-Yehoshua Josfesberg 1, Dalia Galiani 1, Shlomi Lazar 1, Orit Kaufman 1, Rony Seger 1, Nava Dekel 2*
1 Weizmann Inst of Science
2 Weizmann Institute of Science

* To whom correspondence should be addressed. E-mail: nava.dekel{at}weizmann.ac.il.

Abstract

Meiosis is a particular example of a cell cycle, characterized by two successive divisions without an intervening interphase. Resumption of meiosis in oocytes is associated with activation of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK). The activity of MPF declines during the transition between the two meiotic divisions, whereas MAPK activity is sustained. Attempts to disclose the interplay between these key regulators of meiosis in both amphibian and mammalian oocytes generated contradictory results. Furthermore, the enzyme that governs the suppression of interphase in mammals is still unidentified. We provide herein the first demonstration in a mammalian system that inhibition of MPF at reinitiation of meiosis abrogated Mos expression and MAPK activation. We also show that oocytes, in which reactivation of MPF at completion of the first telophase was prevented, exhibited an interphase nucleus with decondensed chromosomes. Inhibition of MAPK did not interfere with the progression to the second meiotic metaphase, but rather resulted in parthenogenic activation. We conclude that in rat oocytes, MPF regulates MAPK activation and its timely reactivation prevents the oocytes from entering interphase.



Key words: Ovary • Cyclic adenosine monophosphate • Meiosis • Oocyte development


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