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BOR - Papers in Press, published online ahead of print November 27, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.008219
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Submitted June 5, 2002
Returned for revision July 2, 2002
Accepted November 14, 2002

Mechanisms of Hormone Action


Effects of Luteinizing Hormone and Follicle Stimulating Hormone and Insulin-Like Growth Factor-I on Aromatase Activity and P450 Aromatase Gene Expression in the Ovarian Follicles of Red Seabream, Pagrus major

Hirohiko Kagawa 1*, Koichiro Gen 2, Koichi Okuzawa 2, Hideki Tanaka 1
1 National Research Institute of Aquaculture
2 Inland Station, National Research Institute of Aquaculture

* To whom correspondence should be addressed. E-mail: hkagawa{at}fra.affrc.go.jp.

Abstract

To clarify the mechanism of estradiol-17{beta} production in the ovarian follicle of red seabream, in vitro effects of luteinizing hormone (LH), follicle stimulating hormone (FSH), and insulin-like growth factor (IGF-I) on aromatase activity (conversion of testosterone to estradiol-17{beta}) and cytochrome P450 aromatase (P450arom) mRNA expression in ovarian fragments of red seabream were investigated. Of the growth factors used in the present study only IGF-I stimulated both aromatase activity and P450arom gene expression in the ovarian fragments of red seabream. LH from red seabream pituitary, but not FSH, stimulated both aromatase activity and P450arom gene expression. IGF-I slightly enhanced the LH-induced aromatase activity and P450arom gene expression. These data and our previous results indicate that LH, but not FSH, stimulates estradiol-17{beta} production in the ovarian follicle of red seabream through stimulation of aromatase activity and P450arom gene expression and IGF-I enhance the LH-stimulated P450arom gene expression.



Key words: Estradiol • Follicle-stimulating hormone • Growth factors • Luteinizing hormone • Oocyte development


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