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BOR - Papers in Press, published online ahead of print February 19, 2003.
Biol Reprod 2003, 10.1095/biolreprod.102.008482
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Submitted June 17, 2002
Returned for revision July 6, 2002
Accepted February 12, 2003

Male Reproductive Tract


EP2 Splicing Variants in Rhesus Monkey (Macaca mulatta) Epididymis

Otto Fröhlich *, Nasreldin M. Ibrahim , Leona G. Young

* To whom correspondence should be addressed. E-mail: froehlich{at}physio.emory.edu.

Abstract

The expression pattern of EP2 variants was examined in the rhesus monkey (Macaca mulatta). Using RT-PCR and RACE protocols, 11 message variants were identified in rhesus epididymis, only three of which (EP2B, EP2C and EP2E) have previously been reported. The most abundant variant found in human, EP2A, was not found in rhesus. Seven of the eight new rhesus EP2 variants (EP2J - EP2Q) use previously unidentified 5'-splicing sites in exon 3, and four variants use three previously unidentified exons whose counterparts are present in the human EP2 gene. Overall, three of the eleven variants, EP2C, EP2E and EP2Q code for b-defensin-like peptides whose probable physiological role is to protect the male reproductive tract against microbial invasions. Because of the complex splicing pattern that causes some downstream exons to be read in any of the three reading frames, the N-termini of the other eight EP2 peptide variants consist of a partial b-defensin motif with three cysteines, followed by amino acid sequences that have no recognizable homology to known proteins.



Key words: Male Reproductive Tract • Epididymis • Gene regulation


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