Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print October 14, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.009316
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
68/1/24    most recent
biolreprod.102.009316v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, J. J.
Right arrow Articles by Unterman, T. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, J. J.
Right arrow Articles by Unterman, T. G.
Agricola
Right arrow Articles by Kim, J. J.
Right arrow Articles by Unterman, T. G.
Submitted July 11, 2002
Returned for revision August 7, 2002
Accepted August 12, 2002

Female Reproductive Tract


Regulation of Insulin-Like Growth Factor Binding Protein-1 Promoter Activity by FKHR and HOXA10 in Primate Endometrial Cells

J. Julie Kim 1, Hugh S. Taylor 2, G. Eda Akbas 2, Isabelle Foucher 3, Alain Trembleau 3, Randal C. Jaffe 1, Asgi T. Fazleabas 1*, Terry G. Unterman 1
1 University of Illinois at Chicago
2 Yale University
3 CNRS UMR 8542, Ecole Normale Superieure

* To whom correspondence should be addressed. E-mail: asgi{at}uic.edu.

Abstract

Insulin-like growth factor binding protein-1 (IGFBP-1) is abundantly expressed in the liver and decidualized endometrium. FKHR, a FOXO forkhead transcription factor, stimulates IGFBP-1 promoter activity in liver cells through the insulin response sequences (IRSs). HOXA10, a homeobox transcription factor is important in the decidualization process. Here we show that FKHR and HOXA10 are expressed in the baboon endometrium during the menstrual cycle and pregnancy. Levels are lowest during the follicular phase and highest in pregnancy. Reporter gene studies reveal that FKHR stimulates both baboon and human IGFBP-1 promoter activity, while HOXA10 alone has a relatively weak effect. When FKHR and HOXA10 are expressed together, promoter activity is markedly upregulated, indicative of cooperativity. A DNA binding-deficient FKHR mutant fails to stimulate promoter activity, even in the presence of HOXA10 and deletion or mutation of IRSs also disrupts the effect of FKHR and cooperativity with HOXA10. Conversely, the IRS region placed upstream of the 31 bp IGFBP-1 minimal promoter is sufficient to mediate effects of FKHR and cooperativity with HOXA10. Pull-down studies reveal physical association between GST-FKHR and 35S-HOXA10. These studies show that FKHR and HOXA10 interact directly and can function cooperatively to stimulate IGFBP-1 promoter activity in endometrial cells and perhaps in other settings.



Key words: Female Reproductive Tract • Decidua • Gene regulation • Implantation • Uterus


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. Zhou, Q. Zhong, P. Minoo, C. Li, D. K. Ann, B. Frenkel, E. E. Morrisey, E. D. Crandall, and Z. Borok
Foxp2 Inhibits Nkx2.1-Mediated Transcription of SP-C via Interactions with the Nkx2.1 Homeodomain
Am. J. Respir. Cell Mol. Biol., June 1, 2008; 38(6): 750 - 758.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
Z. Lu, J. Hardt, and J.J. Kim
Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation
Mol. Hum. Reprod., June 1, 2008; 14(6): 357 - 366.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Takano, Z. Lu, T. Goto, L. Fusi, J. Higham, J. Francis, A. Withey, J. Hardt, B. Cloke, A. V. Stavropoulou, et al.
Transcriptional Cross Talk between the Forkhead Transcription Factor Forkhead Box O1A and the Progesterone Receptor Coordinates Cell Cycle Regulation and Differentiation in Human Endometrial Stromal Cells
Mol. Endocrinol., October 1, 2007; 21(10): 2334 - 2349.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
G B Godbole, D N Modi, and C P Puri
Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli
Reproduction, September 1, 2007; 134(3): 513 - 523.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
J.J. Kim, H.S. Taylor, Z. Lu, O. Ladhani, J.M. Hastings, K.S. Jackson, Y. Wu, S.W. Guo, and A.T. Fazleabas
Altered expression of HOXA10 in endometriosis: potential role in decidualization
Mol. Hum. Reprod., May 1, 2007; 13(5): 323 - 332.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Kajihara, M. Jones, L. Fusi, M. Takano, F. Feroze-Zaidi, G. Pirianov, H. Mehmet, O. Ishihara, J. M. Higham, E. W.-F. Lam, et al.
Differential Expression of FOXO1 and FOXO3a Confers Resistance to Oxidative Cell Death upon Endometrial Decidualization
Mol. Endocrinol., October 1, 2006; 20(10): 2444 - 2455.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
O. L. Buzzio, Z. Lu, C. D. Miller, T. G. Unterman, and J. J. Kim
FOXO1A Differentially Regulates Genes of Decidualization
Endocrinology, August 1, 2006; 147(8): 3870 - 3876.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
J J Brosens and B Gellersen
Death or survival - progesterone-dependent cell fate decisions in the human endometrial stroma.
J. Mol. Endocrinol., June 1, 2006; 36(3): 389 - 398.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
G. S. Daftary and H. S. Taylor
Endocrine Regulation of HOX Genes
Endocr. Rev., June 1, 2006; 27(4): 331 - 355.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. L. Sarno, F. Schatz, C. J. Lockwood, S.-T. J. Huang, and H. S. Taylor
Thrombin and Interleukin-1{beta} Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor
J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2366 - 2372.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
B. Zhao, D. Koon, and K. E Bethin
Identification of transcription factors at the site of implantation in the later stages of murine pregnancy.
Reproduction, March 1, 2006; 131(3): 561 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Labied, T. Kajihara, P. A. Madureira, L. Fusi, M. C. Jones, J. M. Higham, R. Varshochi, J. M. Francis, G. Zoumpoulidou, A. Essafi, et al.
Progestins Regulate the Expression and Activity of the Forkhead Transcription Factor FOXO1 in Differentiating Human Endometrium
Mol. Endocrinol., January 1, 2006; 20(1): 35 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J.J. Kim, O.L. Buzzio, S. Li, and Z. Lu
Role of FOXO1A in the Regulation of Insulin-Like Growth Factor-Binding Protein-1 in Human Endometrial Cells: Interaction with Progesterone Receptor
Biol Reprod, October 1, 2005; 73(4): 833 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. L. Sarno, H. J. Kliman, and H. S. Taylor
HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes
J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 522 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
K. Shazand, S. Baban, C. Prive, B. Malette, P. Croteau, M. Lagace, J.-B. Racine, and P. Hugo
FOXO1 and c-jun transcription factors mRNA are modulated in endometriosis
Mol. Hum. Reprod., December 1, 2004; 10(12): 871 - 877.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. Maruyama, Y. Yamamoto, A. Shimizu, H. Masuda, N. Sakai, R. Sakurai, H. Asada, and Y. Yoshimura
Pyrazolo Pyrimidine-Type Inhibitors of Src Family Tyrosine Kinases Promote Ovarian Steroid-Induced Differentiation of Human Endometrial Stromal Cells In Vitro
Biol Reprod, January 1, 2004; 70(1): 214 - 221.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W.-C. Tsai, N. Bhattacharyya, L.-Y. Han, J. A. Hanover, and M. M. Rechler
Insulin Inhibition of Transcription Stimulated by the Forkhead Protein Foxo1 Is Not Solely due to Nuclear Exclusion
Endocrinology, December 1, 2003; 144(12): 5615 - 5622.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Foucher, M. L. Montesinos, M. Volovitch, A. Prochiantz, and A. Trembleau
Joint regulation of the MAP1B promoter by HNF3{beta}/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors
Development, May 1, 2003; 130(9): 1867 - 1876.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2002 by the Society for the Study of Reproduction.