Biol Reprod Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

BOR - Papers in Press, published online ahead of print October 31, 2002.
Biol Reprod 2002, 10.1095/biolreprod.102.010371
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
68/4/1087    most recent
biolreprod.102.010371v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lui, W.-y.
Right arrow Articles by Cheng, C. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lui, W.-y.
Right arrow Articles by Cheng, C. Y.
Agricola
Right arrow Articles by Lui, W.-y.
Right arrow Articles by Cheng, C. Y.
Submitted August 14, 2002
Returned for revision August 30, 2002
Accepted October 30, 2002

Minireview


Sertoli Cell Tight Junction Dynamics: Their Regulation During Spermatogenesis

Wing-yee Lui 1, Dolores Mruk 1, Will M. Lee 2, C. Yan Cheng 1*
1 Population Council
2 University of Hong Kong

* To whom correspondence should be addressed. E-mail: y-cheng{at}popcbr.rockefeller.edu.

Abstract

During spermatogenesis, developing preleptotene and leptotene spermatocytes must translocate from the basal to the adluminal compartment of the seminiferous epithelium so that fully developed spermatids (spermatozoa) can be released to the tubular lumen at spermiation. It is conceivable that the opening and closing of the inter-Sertoli tight junctions (TJs) that constitute the BTB are regulated by an array of molecules and intriguingly coordinated signaling pathways. Yet, the mechanism(s) that regulates these events is virtually not known. This minireview summarizes some of the recent advances in the study of TJ dynamics in the testis. For instance, several molecules, such as TGF-{beta}3, occludin, protein kinase A and protein kinase C, and signaling pathways, such as TGF-{beta}3/p38 MAP kinase pathway, have been shown to regulate Sertoli cell TJ dynamics. Several models that can be used to study TJ dynamics are also reviewed. This minireview also highlights specific areas of research that deserve attention in future studies in understanding the precise physiological relationship between junction dynamics and spermatogenesis.



Key words: Testis • Sertoli cells • Signal transduction • Spermatogenesis


This article has been cited by other articles:


Home page
 ReproductionHome page
G. A Tarulli, S. J Meachem, S. Schlatt, and P. G Stanton
Regulation of testicular tight junctions by gonadotrophins in the adult Djungarian hamster in vivo
Reproduction, June 1, 2008; 135(6): 867 - 877.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
T. J Kaitu'u-Lino, P. Sluka, C. F H Foo, and P. G Stanton
Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro
Reproduction, June 1, 2007; 133(6): 1169 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. H. Volle, K. Mouzat, R. Duggavathi, B. Siddeek, P. Dechelotte, B. Sion, G. Veyssiere, M. Benahmed, and J.-M. A. Lobaccaro
Multiple Roles of the Nuclear Receptors for Oxysterols Liver X Receptor to Maintain Male Fertility
Mol. Endocrinol., May 1, 2007; 21(5): 1014 - 1027.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
K. Nagaosa, A. Kishimoto, R. Kizu, A. Nakagawa, A. Shiratsuchi, and Y. Nakanishi
Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice
Reproduction, January 1, 2007; 133(1): 21 - 27.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
K. Acevedo, N. Moussi, R. Li, P. Soo, and O. Bernard
LIM Kinase 2 Is Widely Expressed in All Tissues
J. Histochem. Cytochem., May 1, 2006; 54(5): 487 - 501.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Kato, T. Maeda, T. Akaike, and I. Tamai
Characterization of novel Na+-dependent nucleobase transport systems at the blood-testis barrier
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E968 - E975.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. A. Tarulli, P. G. Stanton, A. Lerchl, and S. J. Meachem
Adult Sertoli Cells Are Not Terminally Differentiated in the Djungarian Hamster: Effect of FSH on Proliferation and Junction Protein Organization
Biol Reprod, May 1, 2006; 74(5): 798 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Meng, R. W. Holdcraft, J. E. Shima, M. D. Griswold, and R. E. Braun
Androgens regulate the permeability of the blood-testis barrier
PNAS, November 15, 2005; 102(46): 16696 - 16700.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. J Meachem, S. M Ruwanpura, J. Ziolkowski, J. M Ague, M. K Skinner, and K. L Loveland
Developmentally distinct in vivo effects of FSH on proliferation and apoptosis during testis maturation
J. Endocrinol., September 1, 2005; 186(3): 429 - 446.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. K. Y. Siu, C.-h. Wong, W. M. Lee, and C. Y. Cheng
Sertoli-Germ Cell Anchoring Junction Dynamics in the Testis Are Regulated by an Interplay of Lipid and Protein Kinases
J. Biol. Chem., July 1, 2005; 280(26): 25029 - 25047.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
K. M. Wolski, C. Perrault, R. Tran-Son-Tay, and D. F. Cameron
Strength Measurement of the Sertoli-Spermatid Junctional Complex
J Androl, May 1, 2005; 26(3): 354 - 359.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C.-h. Wong, D. D. Mruk, M. K. Y. Siu, and C. Y. Cheng
Blood-Testis Barrier Dynamics Are Regulated by {alpha}2-Macroglobulin via the c-Jun N-Terminal Protein Kinase Pathway
Endocrinology, April 1, 2005; 146(4): 1893 - 1908.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. Kato, T. Maeda, T. Akaike, and I. Tamai
Nucleoside Transport at the Blood-Testis Barrier Studied with Primary-Cultured Sertoli Cells
J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 601 - 608.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
T. Sato, Y. Kanai, T. Noma, M. Kanai-Azuma, S. Taya, T. Matsui, M. Ishii, H. Kawakami, M. Kurohmaru, K. Kaibuchi, et al.
A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary
Reproduction, November 1, 2004; 128(5): 583 - 594.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Z.M. Lei, S. Mishra, P. Ponnuru, X. Li, Z.W. Yang, and Ch.V. Rao
Testicular Phenotype in Luteinizing Hormone Receptor Knockout Animals and the Effect of Testosterone Replacement Therapy
Biol Reprod, November 1, 2004; 71(5): 1605 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. D. Mruk and C. Y. Cheng
Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis
Endocr. Rev., October 1, 2004; 25(5): 747 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. P.Y. Lee and C. Y. Cheng
Adaptors, Junction Dynamics, and Spermatogenesis
Biol Reprod, August 1, 2004; 71(2): 392 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. K.Y. Siu and C. Y. Cheng
Interactions of Proteases, Protease Inhibitors, and the {beta}1 Integrin/Laminin {gamma}3 Protein Complex in the Regulation of Ectoplasmic Specialization Dynamics in the Rat Testis
Biol Reprod, April 1, 2004; 70(4): 945 - 964.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C.-h. Wong, D. D. Mruk, W.-y. Lui, and C. Y. Cheng
Regulation of blood-testis barrier dynamics: an in vivo study
J. Cell Sci., February 15, 2004; 117(5): 783 - 798.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. P.Y. Lee and C. Y. Cheng
Nitric Oxide/Nitric Oxide Synthase, Spermatogenesis, and Tight Junction Dynamics
Biol Reprod, February 1, 2004; 70(2): 267 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. A. Westbrook, P. D. Schoppee, A. B. Diekman, K. L. Klotz, M. Allietta, K. T. Hogan, C. L. Slingluff, J. W. Patterson, H. F. Frierson, W. P. Irvin Jr., et al.
Genomic Organization, Incidence, and Localization of the SPAN-X Family of Cancer-Testis Antigens in Melanoma Tumors and Cell Lines
Clin. Cancer Res., January 1, 2004; 10(1): 101 - 112.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2002 by the Society for the Study of Reproduction.