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Adult Follitropin Receptor Knock Out (FORKO) female mice
are infertile and estrogen deficient. In order to
understand the peri/postnatal developmental changes we
have now characterized the structural and molecular
aberrations by comparing several markers of follicular
development in 2, 10 and 24-day-old wild type and FORKO
females. By day 24 FORKO mice have 40-50% smaller uteri
and vagina. Estradiol is undetectable but testosterone
and LH levels are already elevated at this age. FORKO
ovaries are 45% smaller indicating a postnatal or
perinatal deficit consequent to FSH receptor ablation.
This is attributable to decreased number of growing
follicles and reduced diameter. Developmental markers,
such as Müllerian Inhibiting Substance, GATA-4,
estrogen receptor 
, and androgen receptor, were
differentially expressed in granulosa cells. In the 2-day-
old mutant neonates a faster recruitment process was
noted that later slowed down impeding development of
follicles. This is noteworthy in light of the controversy
regarding the direct role of FSH/receptor system as a
determinant of small and preantral follicle development
in rodents. As the pool of non-growing primordial
follicles specifies the duration of female fertility and
timing of reproductive senescence, we believe that the
postnatal FORKO female mouse could help in exploring the
signals that impact on early folliculogenesis. In
addition, our data suggests that the FSH/receptor system
is a major contributor to the formation and recruitment
of the non-growing pool of follicles as early as
postnatal day 2 in the mouse.
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