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BOR - Papers in Press, published online ahead of print July 9, 2003.
Biol Reprod 2003, 10.1095/biolreprod.103.019877
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Jeremy O. Ward
Laura G. Reinholdt
Suzanne A. Hartford
Lawriston A. Wilson
Robert J. Munroe
Kerry J. Schimenti
Marilyn O'Brien
Janice K. Pendola
John Eppig
John C. Schimenti
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Submitted June 2, 2003
Returned for revision June 29, 2003
Accepted July 8, 2003

Gamete Biology


Towards the Genetics of Mammalian Reproduction: Induction and Mapping of Gametogenesis Mutants in Mice

Jeremy O. Ward , Laura G. Reinholdt , Suzanne A. Hartford , Lawriston A. Wilson , Robert J. Munroe , Kerry J. Schimenti , Brian J. Libby , Marilyn O'Brien , Janice K. Pendola , John Eppig , and John C. Schimenti *

* To whom correspondence should be addressed. E-mail: jcs{at}jax.org.

Abstract
The genetic control of mammalian gametogenesis is inadequately characterized due a lack of mutations causing infertility. To further the discovery of the genes required for mammalian gametogenesis, phenotype-driven screens were performed in mice, using random chemical mutagenesis of whole animals and ES cells. Eleven initial mutations are reported here that affect proliferation of germ cells, meiosis, spermiogenesis, and spermiation. Nine have been mapped genetically. These preliminary studies provide baselines for estimating the number of genes required for gametogenesis, and offer guidance in conducting new genetic screens that will accelerate and optimize mutant discovery. This report demonstrates the efficacy and expediency of mutagenesis to identify new genes required for mammalian gamete development.

Key words: Gametogenesis • Meiosis • Oocyte development • Spermatid • Spermatogenesis


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