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BOR - Papers in Press, published online ahead of print October 1, 2003.
Biol Reprod 2003, 10.1095/biolreprod.103.020271
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Yukio Tsunoda
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Submitted June 12, 2003
Returned for revision July 1, 2003
Accepted September 30, 2003

Reproductive Technology


Nuclear Transfer of Adult Bone Marrow Mesenchymal Stem Cells: Developmental Totipotency of Tissue-Specific Stem Cells from an Adult Mammal

Yoko Kato , Hideaki Imabayashi , Taisuke Mori , Tetsuya Tani , Masanori Taniguchi , Mikihiko Higashi , Michio Matsumoto , Akihiro Umezawa , and Yukio Tsunoda *

* To whom correspondence should be addressed. E-mail: tsunoda{at}nara.kindai.ac.jp.

Abstract
Recent studies have demonstrated that somatic stem cells have a flexible potential more than expected before, if they are transplanted into different tissues. On the other hand, recent works also revealed that these potentials might be happen by spontaneous cell fusion with recipient cells. Somatic cells' nuclei could be reprogrammed, when they were artificially or spontaneously fused with mouse embryonic stem (ES) cells. Resulted hybrid cells acquired a developmental pluripotency, that original somatic cells didn't have, but ES-cells did. LaBarge and Blau (1) demonstrated that adult bone marrow-derived cells contributed to muscle tissue in a step-wise biological progression. That means that bone marrow-derived cells became satellite cells of mononucleate muscle stem cells after the first irradiation-induced damage to the mouse, and then after the second induced damage, multinucleate myofibers were appeared from the bone marrow-derived cells. Considering together, differentiation potential of somatic stem cells nucleus itself is still unclear. Although the pluripotency of somatic stem cell populations have been evaluated as shown above even if they were fused with other cells or not, developmental totipotency of nucleus of somatic stem cells was not proven except only one paper concerning with fetal neural cells, but never in adult stem cells. Here we showed the developmental totipotency of adult bovine mesenchymal stem cells by nuclear transfer.

Key words: Embryo • Gamete Biology • Assisted Reproductive Technology • Developmental biology • Early development


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