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BOR - Papers in Press, published online ahead of print January 28, 2004.
Biol Reprod 2004, 10.1095/biolreprod.103.022616
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Submitted August 25, 2003
Returned for revision September 23, 2003
Accepted January 22, 2004

Reproductive Technology


Telomere Lengths in Cloned Transgenic Pigs

Le Jiang , Bart Carter , Jie Xu , Xiangzhong Yang , Randall S. Prather , and X. Cindy Tian *

* To whom correspondence should be addressed. E-mail: xtian{at}canr.uconn.edu.

Abstract
Studies of cloned cattle and mice have resulted in controversies regarding the restoration of eroded telomere length of donor cells by the nuclear transfer process. Little is known about telomere lengths in pigs from either natural reproduction or nuclear transfer. In this study, we measured the telomere lengths in six major porcine organs from animals of different ages, and found that their lengths remained consistent throughout different tissues during fetal stages, and then shortened, in a tissue specific manner, after birth. Telomeres of skin samples from 6 cloned transgenic pigs at 4 months of age did not differ significantly from those of age-matched controls. Two cloned pigs that died shortly after birth had skin telomere lengths equivalent to those of late stage fetuses.

Key words: Assisted Reproductive Technology


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