Ovary

Adamts-1 Is Essential for the Development and Function of the Urogenital System

Abstract
Successful ovulation and implantation processes play a crucial role in female fertility. Adamts-1, a matrix metalloproteinase with disintegrin and thrombospondin motifs, has been suggested to be regulated by the progesterone receptor (PR) in the hormonal pathway leading to ovulation. With the primary aim of investigating the role of Adamts-1 in female fertility, we generated Adamts-1 null mice. Forty-five percent of the newborn Adamts-1 null mice die, with death most likely caused by a kidney malformation that becomes apparent at birth. Surviving female null mice were subfertile, while males reproduced normally. Ovulation in null females was impaired due to mature oocytes remaining trapped in ovarian follicles. No uterine phenotype was apparent in Adamts-1 null animals. Embryo implantation occurred normally, the uteri were capable of undergoing decidualisation and no morphological changes were observed. These results demonstrate that a functional Adamts-1 is required for normal ovulation to occur, and hence the Adamts-1 gene plays an important role in female fertility, primarily during the tissue remodelling process of ovulation.

Key words: Female Reproductive Tract • Ovary • Pregnancy • Ovulation • Uterus

This article has been cited by other articles:

				S.-C. Su, E. A. Mendoza, H.-i. Kwak, and K. J. Bayless Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1215 - C1229. [Abstract] [Full Text] [PDF]

				S. Gao, C. De Geyter, K. Kossowska, and H. Zhang FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles Mol. Hum. Reprod., July 1, 2007; 13(7): 465 - 471. [Abstract] [Full Text] [PDF]

				D. L. Russell and R. L. Robker Molecular mechanisms of ovulation: co-ordination through the cumulus complex Hum. Reprod. Update, May 1, 2007; 13(3): 289 - 312. [Abstract] [Full Text] [PDF]

				C. J. East, H. Stanton, S. B. Golub, F. M. Rogerson, and A. J. Fosang ADAMTS-5 Deficiency Does Not Block Aggrecanolysis at Preferred Cleavage Sites in the Chondroitin Sulfate-rich Region of Aggrecan J. Biol. Chem., March 23, 2007; 282(12): 8632 - 8640. [Abstract] [Full Text] [PDF]

				Q. Li, F. Jimenez-Krassel, A. Bettegowda, J. J Ireland, and G. W Smith Evidence that the preovulatory rise in intrafollicular progesterone may not be required for ovulation in cattle J. Endocrinol., March 1, 2007; 192(3): 473 - 483. [Abstract] [Full Text] [PDF]

				H. Zhu, P.C.K. Leung, and C.D. MacCalman Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines Hum. Reprod., January 1, 2007; 22(1): 63 - 74. [Abstract] [Full Text] [PDF]

				J. Wen, H. Zhu, S. Murakami, P. C. K. Leung, and C. D. MacCalman Regulation of A Disintegrin And Metalloproteinase with ThromboSpondin Repeats-1 Expression in Human Endometrial Stromal Cells by Gonadal Steroids Involves Progestins, Androgens, and Estrogens J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4825 - 4835. [Abstract] [Full Text] [PDF]

				K. Miyakoshi, M. J. Murphy, R. R. Yeoman, S. Mitra, C. J. Dubay, and J. D. Hennebold The Identification of Novel Ovarian Proteases Through the Use of Genomic and Bioinformatic Methodologies Biol Reprod, December 1, 2006; 75(6): 823 - 835. [Abstract] [Full Text] [PDF]

				Z. Xu, Y. Yu, and E. J. Duh Vascular Endothelial Growth Factor Upregulates Expression of ADAMTS1 in Endothelial Cells through Protein Kinase C Signaling. Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 4059 - 4066. [Abstract] [Full Text] [PDF]

				Y. H. Ng, H. Zhu, C. J. Pallen, P. C.K. Leung, and C. D. MacCalman Differential effects of interleukin-1beta and transforming growth factor-beta1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro Hum. Reprod., August 1, 2006; 21(8): 1990 - 1999. [Abstract] [Full Text] [PDF]

				A. X. Torres-Collado, W. Kisiel, M. L. Iruela-Arispe, and J. C. Rodriguez-Manzaneque ADAMTS1 Interacts with, Cleaves, and Modifies the Extracellular Location of the Matrix Inhibitor Tissue Factor Pathway Inhibitor-2 J. Biol. Chem., June 30, 2006; 281(26): 17827 - 17837. [Abstract] [Full Text] [PDF]

				C.-j. Liu, W. Kong, K. Ilalov, S. Yu, K. Xu, L. Prazak, M. Fajardo, B. Sehgal, and P. E. Di Cesare ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein FASEB J, May 1, 2006; 20(7): 988 - 990. [Abstract] [Full Text] [PDF]

				N. V. Lee, J. C. Rodriguez-Manzaneque, S. N.-M. Thai, W. O. Twal, A. Luque, K. M. Lyons, W. S. Argraves, and M. L. Iruela-Arispe Fibulin-1 Acts as a Cofactor for the Matrix Metalloprotease ADAMTS-1 J. Biol. Chem., October 14, 2005; 280(41): 34796 - 34804. [Abstract] [Full Text] [PDF]

				M Shozu, N Minami, H Yokoyama, M Inoue, H Kurihara, K Matsushima, and K Kuno ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary J. Mol. Endocrinol., October 1, 2005; 35(2): 343 - 355. [Abstract] [Full Text] [PDF]

				J. F. Couse, M. M. Yates, B. J. Deroo, and K. S. Korach Estrogen Receptor-{beta} Is Critical to Granulosa Cell Differentiation and the Ovulatory Response to Gonadotropins Endocrinology, August 1, 2005; 146(8): 3247 - 3262. [Abstract] [Full Text] [PDF]

				M. Krampert, S. Kuenzle, S. N.-M. Thai, N. Lee, M. L. Iruela-Arispe, and S. Werner ADAMTS1 Proteinase Is Up-regulated in Wounded Skin and Regulates Migration of Fibroblasts and Endothelial Cells J. Biol. Chem., June 24, 2005; 280(25): 23844 - 23852. [Abstract] [Full Text] [PDF]

				J. S. Richards, I. Hernandez-Gonzalez, I. Gonzalez-Robayna, E. Teuling, Y. Lo, D. Boerboom, A. E. Falender, K. H. Doyle, R. G. LeBaron, V. Thompson, et al. Regulated Expression of ADAMTS Family Members in Follicles and Cumulus Oocyte Complexes: Evidence for Specific and Redundant Patterns During Ovulation Biol Reprod, May 1, 2005; 72(5): 1241 - 1255. [Abstract] [Full Text] [PDF]

				L. Mittaz, S. Ricardo, G. Martinez, I. Kola, D. J. Kelly, M. H. Little, P. J. Hertzog, and M. A. Pritchard Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis Nephrol. Dial. Transplant., February 1, 2005; 20(2): 419 - 423. [Abstract] [Full Text] [PDF]

				K. M. H. Doyle, D. L. Russell, V. Sriraman, and J. S. Richards Coordinate Transcription of the ADAMTS-1 Gene by Luteinizing Hormone and Progesterone Receptor Mol. Endocrinol., October 1, 2004; 18(10): 2463 - 2478. [Abstract] [Full Text] [PDF]

				M. Shimada, M. Nishibori, Y. Yamashita, J. Ito, T. Mori, and J. S. Richards Down-Regulated Expression of A Disintegrin and Metalloproteinase with Thrombospondin-Like Repeats-1 by Progesterone Receptor Antagonist Is Associated with Impaired Expansion of Porcine Cumulus-Oocyte Complexes Endocrinology, October 1, 2004; 145(10): 4603 - 4614. [Abstract] [Full Text] [PDF]