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BOR - Papers in Press, published online ahead of print May 5, 2004.
Biol Reprod 2004, 10.1095/biolreprod.104.029413
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Submitted March 10, 2004
Returned for revision April 9, 2004
Accepted April 21, 2004

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Progress with Non-Human Primate Embryonic Stem Cells

Don P. Wolf *, Hung-Chih Kuo , K.-Y. Francis Pau , and Linda Lester

* To whom correspondence should be addressed. E-mail: wolfd{at}ohsu.edu.

Abstract
Embryonic stem cells hold potential to the fields of regenerative medicine, developmental biology, tissue regeneration, disease pathogenicity and drug discovery. Embryonic stem (ES) cell lines are now available in primates, including man, rhesus and cynomologous monkeys. Monkey ES cells serve as invaluable clinically relevant models for studies that can't be conducted in humans because of practical or ethical limitations or in rodents because of differences in physiology and anatomy. Here, we review the current status of non-human primate research with ES cells beginning with a description of their isolation, characterization and availability. Substantial limitations still plague the use of primate ES cells such as their required growth on feeder layers, poor cloning efficiency and restricted availability. The ability to produce homogenous populations of both undifferentiated as well as differentiated phenotypes is an important challenge and genetic approaches to achieving these objectives are discussed. Finally safety, efficiency and feasibility issues relating to the transplantation of ES derived cells are considered.

Key words: Embryo • Assisted Reproductive Technology • Developmental biology • Early development


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